Results 251 to 260 of about 17,238,583 (283)
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Nuclear factor-kappa B in intestinal protection and destruction
Current Opinion in Gastroenterology, 2009Nuclear factor-kappa B (NF-kappaB) is a key transcriptional regulator of innate and adaptive immunity. This review highlights new insights into the functions of NF-kappaB in normal homeostasis and specific disease processes in the intestinal tract.Inflammatory bowel disease and experimental intestinal inflammation are characterized by NF-kappaB ...
Martina E, Spehlmann, Lars, Eckmann
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Nuclear factor kappa B activation by NADPH oxidases
Mechanisms of Ageing and Development, 2004Reactive oxygen species (ROS) initiate activation of the transcription factor NF-kappaB in a variety of cell systems. Perhaps the most potent biological source of ROS is the NADPH oxidase of phagocytic cells, a multi-component system that catalyzes the formation of superoxide anion.
Robert A, Clark, Anthony J, Valente
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Role of nuclear factor kappa-B in TNF-induced cytoprotection
Cardiovascular Journal of Africa, 2023Ischaemic heart disease (IHD) is a leading cause of death worldwide. Understanding prosurvival signalling pathways that protect against ischaemia-reperfusion injury (IRI) may assist in the development of novel cardioprotective strategies against IHD. In this regard, the transcription factor, nuclear factor kappa-B (NFκB) is activated by tumour necrosis
Roisin, Kelly-Laubscher +3 more
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Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection [PDF]
Journal of Thoracic and Cardiovascular Surgery, 2008 ObjectiveMyocardial ischemia/reperfusion injury remains a vexing problem. Translating experimental strategies that deliver protective agents before the ischemic insult limits clinical applicability. We targeted 2 proteins in the nuclear factor-κB pathway,
Craig Selzman, Albert Baldwin
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The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia
Biological Psychiatry, 2009Many reports suggest that schizophrenia is associated with the inflammatory response mediated by cytokines, and nuclear factor-kappa B (NF-kappaB) regulates the expression of cytokines. However, it remains unclear whether the interaction between NF-kappaB and cytokines is implicated in schizophrenia and whether the effect of neuroleptics treatment for ...
Xue-Qin, Song +4 more
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Nuclear factor kappa B signaling in catabolic disorders
Current Opinion in Clinical Nutrition and Metabolic Care, 2002The nuclear factor kappa B family of inducible transcription factors regulates the expression of many genes. Nuclear factor kappa B has been implicated in autoimmune and inflammatory diseases, infection, cell survival, and cell transformation with subsequent promotion of cancer. In this review, we summarize features of nuclear factor kappa B regulation
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Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis
MHR: Basic science of reproductive medicine, 2007Red (active), black and white endometriotic lesions are characteristic of peritoneal endometriosis. The transcription factor nuclear factor-kappa B (NF-kappaB) activates proinflammatory, proliferative and antiapoptotic genes in many cell types. To determine whether NF-kappaB is activated in peritoneal endometriosis in women, and further ascertain the ...
Reinaldo, González-Ramos +6 more
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The international journal of biochemistry & cell biology, 1997
Nuclear factor-kappa B (NF-kappa B) is a ubiquitous transcription factor that, by regulating the expression of multiple inflammatory and immune genes, plays a critical role in host defence and in chronic inflammatory diseases. It is a heterodimer, present in the cytoplasm in an inactive form complexed to an inhibitory protein, I kappa B.
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Nuclear factor-kappa B (NF-kappa B) is a ubiquitous transcription factor that, by regulating the expression of multiple inflammatory and immune genes, plays a critical role in host defence and in chronic inflammatory diseases. It is a heterodimer, present in the cytoplasm in an inactive form complexed to an inhibitory protein, I kappa B.
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The role of spinal nuclear factor-kappa B in spinal hyperexcitability
NeuroReport, 2006In behavioral experiments, inhibition of nuclear factor-kappaB activation by systemic administration of the IkappaB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrophysiological recordings in anesthetized rats whether spinal application of S1627 influences ...
Andrea, Ebersberger +4 more
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The Role of Nuclear Factor Kappa B (NF-κB) in Development and Treatment of COVID-19: Review
International Journal of Molecular Sciences, 2022Barbara Mroczko +1 more
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