Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +6 more
core +1 more source
Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B. [PDF]
PLoS ONE, 2011 Inflammation and oxidative stress have been implicated in the pathophysiology of Parkinson's disease (PD) and inhibition of microglial activation attenuates degeneration of dopaminergic (DA) neurons in animal models of PD.
Thi A Tran +5 more
doaj +1 more source
Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species [PDF]
, 2002 Kappa-casein plays an essential role in the formation, stabilisation and aggregation of milk micelles. Control of kappa-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other ...
C. Bruce A. Whitelaw, +16 more
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Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John +4 more
core +1 more source
Role of nuclear factor‐kappa B in atherogenesis
Experimental Physiology, 1997 Transcription factors of the nuclear factor‐kappa B (NF‐kappa B)/Rel family have an important function in the regulation of a variety of genes involved in the inflammatory and proliferative responses of cells. Recent studies strongly indicate that the inducible transcription factor NF‐kappa B is involved in the pathogenesis of atherosclerosis ...
K, Brand +4 more
openaire +2 more sources
The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice [PDF]
, 2007 Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target.
Iancu, Cristina M. +9 more
core +1 more source
Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappa B signaling [PDF]
, 2006 Pituitary function has been shown to be regulated by an increasing number of intrapituitary factors, including cytokines. Here we show that the important cytokine TNF-alpha activates prolactin gene transcription in pituitary GH3 cells stably expressing ...
Spiller DG +9 more
core +7 more sources
Expression of Nuclear Factor Kappa B and Survivin in Psoriasis [PDF]
ISRN Dermatology, 2012 Background and Objective. Suppression of apoptosis has been proposed as a mechanism responsible for epidermal thickness in psoriasis. Survivin is a member of the inhibitor of apoptosis family. Nuclear factor kappa B (NF-κB) is one of the transcriptional factors that regulate many genes affecting apoptosis.
Gunduz, Kamer +4 more
openaire +2 more sources
Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]
, 1999 During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Kelly, Ralph A. +15 more
core +1 more source
Potential Role of Nuclear Factor 𝜿B in Diabetic Cardiomyopathy
Mediators of Inflammation, 2011 Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related ...
O. Lorenzo +5 more
doaj +1 more source