Results 91 to 100 of about 2,137,659 (362)

Spd2 assists Spd1 in modulation of RNR architecture but does not regulate deoxynucleotide pools [PDF]

, 2014
In yeasts, small intrinsically disordered proteins (IDPs) modulate ribonucleotide reductase (RNR) activity to ensure an optimal supply of dNTPs for DNA synthesis. The S. pombe Spd1 protein can directly inhibit the large RNR subunit (R1), import the small
Basrai, Beck, Bester, Bähler, Chabes, Danielsson, Elledge, Fairman, Fleck, Halazonetis, Hofer, Holmberg, Holmberg, Håkansson, Kjaerulff, Knutsen, Lee, Liu, Liu, Marguerat, Maundrell, Moreno, Moss, Nestoras, Nielsen, Nordlund, Reichard, Rhind, Salguero, Tompa, Uchiki, Weinberg, Woollard, Wu, Yoshida, Zhao, Zhao, Zolezzi   +37 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A morphological view on mitochondrial protein targeting [PDF]

, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ades, Allmann, Ardail, Ardail, Ardail, Attardi, Baker, Biermans, Biermans, Brdiczka, Brdiczka, Eilers, Glick, Hackenbrock, Hackenbrock, Hackenbrock, Hartl, Hartl, Hines, Hwang, Kellems, Kiebler, Knoll, Lill, Lithgow, Malhotra, Martin, Marzuki, McEnery, Murakami, Nicolay, Ohlendieck, Pain, Pfanner, Pfanner, Pfanner, Pon, Rassow, Rassow, Rassow, Rojo, Schleyer, Schwaiger, Stuart, Suissa, Söllner, Söllner, Söllner, van Venetië, Vestweber, Vestweber, Vignais, Watson, Werner, Wienhues, Zara   +55 more
core   +1 more source

Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins

Scientific Reports, 2016
A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing virus infection.
J. Batra, Shashank Tripathi, Amrita Kumar, J. Katz, N. Cox, R. Lal, S. Sambhara, S. Lal   +7 more
semanticscholar   +1 more source

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins [PDF]

The Journal of Cell Biology, 1997
Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bidirectional transport signal of A1. Recently, a 90-kD protein, transportin, was
M C, Siomi, P S, Eder, N, Kataoka, L, Wan, Q, Liu, G, Dreyfuss   +5 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Analysis of the Activity of Nuclear Export Signals Using Fluorescent BSA Conjugates

BioTechniques, 2002
Here we demonstrate that fluorescein-labeled BSA conjugated with a mixture of nuclear import and export signals can be used to evaluate export activity.
Carl M. Feldherr, Debra Akin
doaj   +1 more source

Nuclear versus cytosolic activity of the yeast Hog1 MAP kinase in response to osmotic and tunicamycin-induced ER stress [PDF]

, 2015
© 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. We examined the physiological significance of the nuclear versus cytosolic localization of the MAPK Hog1p in the ability of yeast cells to cope with ...
García Marqués, Sara, Prieto Alamán, José Antonio, Rández Gil, Francisca   +2 more
core   +1 more source