Results 161 to 170 of about 75,707 (295)

Histone Nuclear Import and Beyond: Multifunctional Roles of Importins. [PDF]

Bioessays
Bernardes N, Chook YM.
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

A multivalent adaptor mechanism drives the nuclear import of proteasomes. [PDF]

Nat Commun
Brunner HL, Kalis RW, Grundmann L, Hodáková Z, Koskova Z, Grishkovskaya I, de Almeida M, Hinterndorfer M, Knaudt H, Höfflin S, Andersch F, Kotisch H, Dickmanns A, Cuylen-Haering S, Zuber J, Haselbach D.   +15 more
europepmc   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

HOS1-mediated both ubiquitination and nuclear-import are crucial to nitrate signaling. [PDF]

Front Mol Biosci
Xie LB, Yang XY, Zhang ZW, Tang XY, Yuan S.   +4 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Structural insights into the nuclear import of ovine gammaherpesvirus 2 ORF73 LANA homologue. [PDF]

J Gen Virol
Nath BK, Schwab RHM, Swarbrick CMD, Pavan S, Rahman N, McSharry BP, Raidal SR, Ariawan D, Tietz O, Das S, Alvisi G, Forwood JK.   +11 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Tunable High‐Performance Metamaterial Filters Based on Novel SRR Architectures

Advanced Science, EarlyView.
Based on two novel SRR configurations and two independent SRR integration approaches, four tunable bandpass metamaterial filters were fabricated with an ultra‐thin ceramic substrate. Among them, SM‐2 achieves over 97% electromagnetic wave transmittance, with a minimal 1.15% deviation in its resonant frequency prediction, making them promising ...
Lingxi Qu, Liya Zheng, Ruopeng Liu, Chunlin Ji, Bin Li   +4 more
wiley   +1 more source

Nuclear import of purified influenza : a viral ribonucleoproteins

, 2006
The influenza A viral ribonucleoprotein (vRNP) is a macromolecular complex composed of nucleoproteins (NPs), heterotrimetric polymerase complexes (PA, PB1, PB2) and a single stranded viral RNA.
Sun, Ying-Hua Betty
core