Results 181 to 190 of about 270,346 (298)

Correction: Temporal gating of nuclear import: How Merkel cell polyomavirus exploits the cell cycle for nuclear entry. [PDF]

PLoS Pathog
Wang K, Eady AN, Amaya I, Stanczak A, Spriggs CC.   +4 more
europepmc   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Proneural-mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import. [PDF]

Neuro Oncol
Bourmeau G, Anezo O, Raymond J, Ballestín A, Pichol-Thievend C, Reveilles J, Thomas A, Wang L, Miranda M, Moutaux E, Liva S, Ribecco V, Besse L, Dingli F, Loew D, Vallot C, Gargiulo G, Ravi VM, Joseph K, Seano G.   +19 more
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2. [PDF]

J Cell Sci
Shrestha BK, Sjøttem E, Olsvik HL, Odonkor I, Øvervatn A, Brenne HB, Bruun JA, Lamark T, Johansen T.   +8 more
europepmc   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Structural Insights into the Nuclear Import of Haliotid Herpesvirus 1 Large Tegument Protein Homologue. [PDF]

Viruses
Nath BK, Swarbrick CMD, Schwab RHM, Ariawan D, Tietz O, Forwood JK, Sarker S.   +6 more
europepmc   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

PCV2 Cap protein nuclear import via importin α/β receptor: molecular insights and antiviral potential. [PDF]

Front Microbiol
Lin C, Li N, Tao L, Li H, Ma J, Wu C, Zhang F, Fang S, Tan J, Huang Y, Zeng X, Zeng Y.   +11 more
europepmc   +1 more source