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Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme. [PDF]
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Ultrastructural nuclear import assay
Methods, 2006Electron microscopy (EM) has been used for several decades to study the mechanisms of nuclear transport. In early studies of nuclear import, gold-conjugated nuclear proteins were microinjected into cells and followed by EM. As the components of the nuclear pore complex (NPC) and soluble mediators of nuclear import were cloned and characterized, gold ...
Hualin, Zhong +2 more
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Karyopherins and nuclear import
Current Opinion in Structural Biology, 2001Proteins of the karyopherin alpha and karyopherin beta families play a central role in nucleocytoplasmic transport. Recently, crystal structures of karyopherin alpha and its complexes with nuclear localization signal peptides, a karyopherin beta2-Ran complex and complexes of full-length and fragments of karyopherin beta1 with import substrates, Ran and
Y M, Chook, G, Blobel
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Advanced Drug Delivery Reviews, 2003
Many viruses replicate in the nucleus of their host cells. To gain access to this compartment, they must navigate their way from the cell surface, through the endosomal or plasma membrane, across a crowded cytoplasm and finally cross the nuclear envelope.
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Many viruses replicate in the nucleus of their host cells. To gain access to this compartment, they must navigate their way from the cell surface, through the endosomal or plasma membrane, across a crowded cytoplasm and finally cross the nuclear envelope.
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Mechanisms of nuclear protein import
Current Opinion in Cell Biology, 1995The past two years have seen a significant increase in our understanding of nuclear protein import. Five cytosolic import factors have been identified, two of which have been shown to directly interact with components of the nuclear pore complex. These findings enable refinement of previous models for steps in the nuclear import pathway, and provide a ...
F, Melchior, L, Gerace
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Nuclear Import in Viral Infections
2005The separation of transcription in the nucleus and translation in the cytoplasm requires nucleo-cytoplasmic exchange of proteins and RNAs. Viruses have evolved strategies to capitalize on the nucleo-cytoplasmic trafficking machinery of the cell. Here, we first discuss the principal mechanisms of receptor-mediated nuclear import of proteinaceous cargo ...
Greber, U F, Fornerod, M
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2007
Entry into the eukaryotic cell nucleus occurs through multiple pathways involving specific targeting signals, and intracellular receptor molecules of the importin/karyopherin superfamily which recognise and dock the nuclear import substrates carrying these signals at the nuclear pore.
David A. Jans, Jade K. Forwood
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Entry into the eukaryotic cell nucleus occurs through multiple pathways involving specific targeting signals, and intracellular receptor molecules of the importin/karyopherin superfamily which recognise and dock the nuclear import substrates carrying these signals at the nuclear pore.
David A. Jans, Jade K. Forwood
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KPNB1-mediated nuclear import in cancer
European Journal of Pharmacology, 2023Dysregulation of nucleocytoplasmic shuttling impairs cellular homeostasis and promotes cancer development. KPNB1 is a member of karyopherin β family, mediating the transportation of proteins from the cytoplasm to the nucleus. In a variety of cancers, the expression of KPNB1 is upregulated to facilitate tumor growth and progression.
Qiwen Shi +7 more
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Nuclear import and export pathways
Journal of Cellular Biochemistry, 1999Macromolecules enter or leave the nucleus by using nuclear localization signals (NLS), or nuclear export signals (NES), respectively. Different types of NLS and NES are recognized directly or indirectly via adapters, by transport receptors. All transport receptors identified thus far are members of the same family and share an ability to shuttle ...
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Astrophysically important nuclear reactions
Progress in Particle and Nuclear Physics, 2007Abstract Nuclear fusion reactions generate the energies by which stars stabilize during their long lives in hydrostatic equilibrium. In late-stage stellar evolution and during core collapse of massive stars nuclear reactions mediated by the weak force are essential.
K. Langanke +3 more
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