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Control of nuclear import and phytochromes
Current Opinion in Plant Biology, 2000The past year has brought significant changes in our understanding of the molecular mechanism of photoreceptor-regulated gene expression in higher plants. The light-quantity- and light-quality-dependent nuclear import of phytochromes, followed by the conformation-dependent direct interaction of these phytochromes with transcription factors, seems to ...
F, Nagy, E, Schäfer
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Role of the cytoskeleton in nuclear import
Advanced Drug Delivery Reviews, 2003The role of the cytoskeleton in regulating the intracellular localization of cellular organelles, viruses, and individual proteins has been the subject of much investigation in recent years. While regulated transport through the nuclear pore remains the primary determinant of nuclear localization, it has become clear that the nuclear localization of ...
Edward M, Campbell, Thomas J, Hope
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Apoptosis: The importance of nuclear medicine
Nuclear Medicine Communications, 2000Apoptosis is a genetically controlled, energy-dependent process which removes unwanted cells from the body. Because of its orderly progression, apoptosis is also known as programmed cell death or cell suicide. Once initiated, apoptosis is characterized by a series of biochemical and morphological changes involving the cytoplasm, nucleus and cell ...
F G, Blankenberg +3 more
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Ultrastructural nuclear import assay
Methods, 2006Electron microscopy (EM) has been used for several decades to study the mechanisms of nuclear transport. In early studies of nuclear import, gold-conjugated nuclear proteins were microinjected into cells and followed by EM. As the components of the nuclear pore complex (NPC) and soluble mediators of nuclear import were cloned and characterized, gold ...
Hualin, Zhong +2 more
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Advanced Drug Delivery Reviews, 2003
Many viruses replicate in the nucleus of their host cells. To gain access to this compartment, they must navigate their way from the cell surface, through the endosomal or plasma membrane, across a crowded cytoplasm and finally cross the nuclear envelope.
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Many viruses replicate in the nucleus of their host cells. To gain access to this compartment, they must navigate their way from the cell surface, through the endosomal or plasma membrane, across a crowded cytoplasm and finally cross the nuclear envelope.
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Cellular and Molecular Life Sciences, 2021
The majority of lncRNAs and a small fraction of mRNAs localize in the cell nucleus to exert their functions. A SIRLOIN RNA motif was previously reported to drive its nuclear localization by the RNA-binding protein hnRNPK. However, the underlying mechanism remains unclear.
Jialin Yao +6 more
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The majority of lncRNAs and a small fraction of mRNAs localize in the cell nucleus to exert their functions. A SIRLOIN RNA motif was previously reported to drive its nuclear localization by the RNA-binding protein hnRNPK. However, the underlying mechanism remains unclear.
Jialin Yao +6 more
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Regulation of nuclear import and export
2001Publisher Summary An exchange of molecules between the nucleus and cytoplasm is indispensable for gene regulation and normal cell growth and development. Transcription of RNA from DNA occurs in the nucleus, while translation of RNA into protein occurs on cytoplasmic ribosomes. Many proteins rapidly shuttle between the nucleus and cytoplasm, and their
T D, Sweitzer, D C, Love, J A, Hanover
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Nuclear import and export pathways
Journal of Cellular Biochemistry, 1999Macromolecules enter or leave the nucleus by using nuclear localization signals (NLS), or nuclear export signals (NES), respectively. Different types of NLS and NES are recognized directly or indirectly via adapters, by transport receptors. All transport receptors identified thus far are members of the same family and share an ability to shuttle ...
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KPNB1-mediated nuclear import in cancer
European Journal of Pharmacology, 2023Dysregulation of nucleocytoplasmic shuttling impairs cellular homeostasis and promotes cancer development. KPNB1 is a member of karyopherin β family, mediating the transportation of proteins from the cytoplasm to the nucleus. In a variety of cancers, the expression of KPNB1 is upregulated to facilitate tumor growth and progression.
Qiwen Shi +7 more
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Mechanisms of Receptor‐Mediated Nuclear Import and Nuclear Export
Traffic, 2005Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is mediated by a superfamily of transport receptors known collectively as karyopherins. Karyopherins bind to their cargoes by recognition of specific nuclear localization signals or nuclear export signals.
Lucy F, Pemberton, Bryce M, Paschal
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