Results 81 to 90 of about 2,137,659 (362)
Nuclear Import of Hepatitis B Virus Capsids and Genome
Viruses, 2017 Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus.
Lara Gallucci, M. Kann
semanticscholar +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection
PLoS Pathogens, 2016 Following envelope mediated fusion, the HIV-1 core is released into the cytoplasm of the target cell and undergoes a series of trafficking and replicative steps that result in the nuclear import of the viral genome, which ultimately leads to the ...
A. Dharan +6 more
semanticscholar +1 more source
Differential nuclear import regulates nuclear RNA inheritance following mitosis
Molecular Biology of the Cell, 2023 The authors investigate inheritance of nuclear RNA by G1 cells following mitosis. They find that multiple pathways regulate differential inheritance of nuclear RNAs.
Michael D. Blower +2 more
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Trimethylguanosine nucleoside inhibits cross-linking between snurportin 1 and m3G-capped U1 snRNA [PDF]
, 2015 Macromolecular nuclear import is an energy-and signal-dependent process. The best characterized type of nuclear import consists of proteins carrying the classical NLS that is mediated by the heterodimeric receptor importin α/β. Spliceosomal snRNPs U1, U2,
Aviñó, Anna +4 more
core +2 more sources
Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD
Human Molecular Genetics, 2016 A repeat expansion in the non-coding region of C9orf72 gene is the most common mutation causing frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).
Bahram Khosravi +8 more
semanticscholar +1 more source
Nature Methods, 2007 Crystal structures of a transporter with different substrates lead to the design of a pathway-specific nuclear import inhibitor.
openaire +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Dimerization and nuclear entry of mPER proteins in mammalian cells [PDF]
, 2000 Nuclear entry of circadian oscillatory gene products is a key step for the generation of a 24-hr cycle of the biological clock. We have examined nuclear import of clock proteins of the mammalian period gene family and the effect of ...
Yagita, K. (Kazuhiro) +8 more
core +8 more sources