Results 191 to 200 of about 163,417 (257)

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Characterization and Intracellular Localization of the Epstein-Barr Virus Protein BFLF2: Interactions with BFRF1 and with the Nuclear Lamina

, 2005
Roberta Gonnella, Antonella Farina, Roberta Santarelli, Salvatore Raffa, Regina Feederle, Roberto Bei, Marisa Granato, Andrea Modesti, Luigi Frati, Henri‐Jacques Delecluse, Maria Rosaria Torrisi, Antonio Angeloni, Alberto Faggioni   +12 more
openalex   +1 more source

Holistic Optimization toward Ultrathin Flexible Perovskite Solar Cells with High Efficiency and Mechanical Robustness

Advanced Science, EarlyView.
In this manuscript, 2D perovskite grain boundaries are constructed to improve the intrinsic flexibility of perovskite films by efficiently releasing the strain. In addition, a novel additive, sucralose, is employed to enhance the conductivity and mechanical flexibility of PEDOT:PSS electrodes. Consequently, an ultrathin f‐PSC is successfully fabricated
Guanqi Tang, Fangyuan Zheng, Jiajun Song, Qidong Tai, Jiong Zhao, Feng Yan   +5 more
wiley   +1 more source

Upscaling Perovskite Photovoltaics: from 156 cm2 Modules to 0.73 M2 Panels

Advanced Science, EarlyView.
From lab to sunlight: perovskite photovoltaics are scaled from 156 cm² large area modules to 0.73 m² panels. With 17.68% efficiency at module level and a stron 12% PCE in outdoor conditions, this advance represents a significant step toward real‐world deployment, paving the way from innovation to practical application.
Hafez Nikbakht, Paolo Mariani, Luigi Vesce, Francesco Di Giacomo, Enrico Leonardi, George Viskadouros, Emmanuel Spiliarotis, Konstantinos Rogdakis, Sara Pescetelli, Antonio Agresti, Sebastiano Bellani, Francesco Bonaccorso, Emmanuel Kymakis, Aldo Di Carlo   +13 more
wiley   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Nanoparticle Delivery of Antisense miR162 Inhibits Invasive Habitat Adaption of Alternanthera Philoxeroides

Advanced Science, EarlyView.
This study demonstrates that the miRNA pathway plays a key role in the invasive growth of Alternanthera philoxeroides in aquatic habitats. Specifically, miR162 is critical for its invasive success, facilitating stem elongation and enhancing survival during submergence.
Qianqian Hu, Erfeng Kou, Xiuzhen Liao, Ruiyi Qiu, Qi Tang, Huan Zhang, Yun Zheng, Ji Yang, Binglian Zheng   +8 more
wiley   +1 more source

3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration

Advanced Science, EarlyView.
This study presents 3D‐printed Ti‐6Al‐4V trabecular scaffolds combined with hypoxia‐induced exosomes encapsulated in PEGDA/GelMA microspheres for sustained release. The scaffolds mimic the structure of natural bone, while the exosome delivery system enhances osteogenesis and angiogenesis, significantly promoting bone regeneration and offering a ...
Lincong Luo, Weihan Zheng, Jiaying Li, Tingting Chen, Wanting Xue, Tao Lin, Mingrui Liu, Zi Yan, Jiaxin Yang, Jiamin Li, Jiahao Pu, Yaobin Wu, Konghe Hu, Shiyu Li, Wenhua Huang   +14 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest [PDF]

, 2019
Sang-Kyun Cho, Manasvita Vashisth, Amal Abbas, Stephanie Majkut, Kenneth P. Vogel, Yuntao Xia, Irena L. Ivanovska, Jerome Irianto, Manorama Tewari, Kuangzheng Zhu, Elisia D. Tichy, Foteini Mourkioti, Hsin‐Yao Tang, Roger A. Greenberg, Benjamin L. Prosser, Dennis E. Discher   +15 more
openalex   +1 more source

Diurnal Release of Airborne Pathogen Spores in Greenhouses via the Synergistic Effects of Relative Humidity and Wind

Advanced Science, EarlyView.
Day‐night cycles trigger sharp relative humidity (RH) shifts in greenhouses. Rapid humidity drops dehydrate Corynespora cassiicola spores, inducing shrinkage, jerking movements, and weakened inter‐spore connections that drive detachment. Wind is essential for dispersal, with even mild airflow enabling rapid pathogen spread. These synergistic effects of
Jiayi Ma, Ali Chai, Yanxia Shi, Xuewen Xie, Lei Li, Sheng Xiang, Xianhua Sun, Tengfei Fan, Baoju Li   +8 more
wiley   +1 more source