Structural Basis for the Specificity of Bipartite Nuclear Localization Sequence Binding by Importin-α [PDF]
, 2003 Marcos R.M. Fontes +4 more
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
BSAP (Pax5)-Importin α1 (Rch1) Interaction Identifies a Nuclear Localization Sequence [PDF]
, 2000 Cecilia R. Kovac +4 more
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Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29.
, 2020 Mark Underwood, Howard M. Fried
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Nuclear Targeting of the Maize R Protein Requires Two Nuclear Localization Sequences [PDF]
, 1993 Mark W. Shieh +2 more
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, 2023 Peng Zhou +13 more
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Nuclear Export Signal Consensus Sequences Defined Using a Localization‐Based Yeast Selection System [PDF]
, 2008 Shunichi Kosugi +3 more
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FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source