Results 161 to 170 of about 292,166 (318)

Identification of a Nuclear Localization Sequence in Beta-Arrestin1:Implications in NF- kB Activation

, 2012
A mounting body of evidence suggests that beta-arrestin1 plays important roles in the nucleus, but how beta-arrestin1 enters the nucleus remains unclear since no nuclear import signal has been identified in the -arrestins.
Crystal Z. Hoeppner (7998908)
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Identification of a Nuclear Localization Sequence in β-Arrestin-1 and Its Functional Implications [PDF]

, 2012
Crystal Zoe Hoeppner, Ni Cheng, Richard D. Ye   +2 more
openalex   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Distal protein sequences can affect the function of a nuclear localization signal.

, 1992
Min Gao, David M. Knipe
openalex   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Nuclear positioning and functional regulation of endogenous genes and transgenes in the fruit fly Drosophila melanogaster and in mammalian cells

, 2006
The goal of the work was to address the role of higher order nuclear architecture in the functional regulation of endogenous genes and transgenes in different species.
Rybakina, Elena
core  

The role of emerin and LEM domain proteins in nuclear envelope assembly and cytoskeleton organisation [PDF]

, 2005
The nuclear envelope (NE) plays a fundamental role in the cell by separating nuclear from cytoplasmic activities, and mutations in NE proteins have been associated with a diverse array of diseases.
Saipingidou, Georgia, Salpingidou, Georgia   +1 more
core  

Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

, 2006
BACKGROUND: CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers.
Bergman, Lee M., Jeremy P Blaydes, Mirnezami Alexander H, Alexander H Mirnezami, Bergman Lee M, Samal C Gunatilake, Mirnezami, Alexander H., Darley Matthew, Morris Laila, Lee M Bergman, Laila Morris, Darley, Matthew, Gunatilake, Samal C., Blaydes, Jeremy P., Morris, Laila, Matthew Darley, Gunatilake Samal C, Blaydes Jeremy P   +17 more
core   +1 more source