Results 211 to 220 of about 929,541 (348)

Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Approximately half of patients with hereditary myopathies remain without a definitive genetic diagnosis after DNA next‐generation sequencing (NGS). Here, we implemented transcriptome analysis of muscle biopsies as a complementary diagnostic tool for patients with muscle disease but no definitive genetic diagnosis after exome ...
Alba Segarra‐Casas, Cristina Domínguez‐González, Daniel Natera‐de Benito, Solange Kapetanovic, Aurelio Hernández‐Laín, Berta Estévez‐Arias, Laura Llansó, Carlos Ortez, Cristina Jou, Itxaso Martí‐Carrera, Arístides López‐Márquez, Maria José Rodríguez, Laura González‐Mera, Velina Nedkova, Roberto Fernández‐Torrón, Benjamín Rodríguez‐Santiago, Cecília Jimenez‐Mallebrera, Raul Juntas‐Morales, Adolfo López‐de Munain, Jordi Surrallés, Andrés Nascimento, Eduard Gallardo, Montse Olivé, Pia Gallano, Lidia González‐Quereda   +24 more
wiley   +1 more source

The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice

The FASEB Journal, 2010
R. Toribio, H. A. Brown, C. M. Novince, B. Marlow, Krista M. Hernon, Lisa G. Lanigan, Blake E. Hildreth Iii, J. Werbeck, S. Shu, G. Lorch, M. Carlton, J. Foley, P. Boyaka, L. McCauley, T. Rosol   +14 more
semanticscholar   +1 more source

Pathway Analyses of Inherited Neuropathies Identify Putative Common Mechanisms of Axon Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Inherited neuropathies (IN) are associated with over 100 different genetic mutations presenting with a variety of phenotypes. This complexity suggests multiple pathways may converge onto a limited number of downstream pathways to effect axonal injury.
Christopher R. Cashman, Craig Blackstone, Reza Sadjadi   +2 more
wiley   +1 more source

Antitumor Effects and Normal-Tissue Toxicity of 111In-Nuclear Localization Sequence-Trastuzumab in Athymic Mice Bearing HER-Positive Human Breast Cancer Xenografts

Journal of Nuclear Medicine, 2010
Danny L. Costantini, K. McLarty, Helen Lee, S. Done, K. Vallis, R. Reilly   +5 more
semanticscholar   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered. [PDF]

Arch Biochem Biophys, 2019
Pantoja-Uceda D, Neira JL, Contreras LM, Manton CA, Welch DR, Rizzuti B.   +5 more
europepmc   +1 more source

Icephobic Gradient Polymer Coatings Coupled with Electromechanical De‐icing Systems: A Promising Ice Repellent Hybrid System

Advanced Engineering Materials, EarlyView.
A hybrid system for de‐icing made of gradient polymer coatings, deposited on aluminum coupled with an electromechanical system, is demonstrated as an effective and durable strategy for reducing drastically ice adhesion. The system is capable of detaching ice blocks over the coating in less than 1 s, regardless of the ice type and covered area ...
Gabriel Hernández Rodríguez, Giulia Gastaldo, Luca Stendardo, Younes Rafik, Jason Pothin, Marc Budinger, Carlo Antonini, Valérie Pommier‐Budinger, Anna Maria Coclite   +8 more
wiley   +1 more source

Comparative Wear and Friction Analysis of Sliding Surface Materials for Hydrostatic Bearing under Oil Supply Failure Conditions

Advanced Engineering Materials, EarlyView.
Hydrostatic bearings excel in high‐precision applications, but their performance hinges on a continuous external supply. This study evaluates various material combinations for sliding surfaces to mitigate damage during supply failures or misalignment and to discover the most effective materials identified for enhancing the reliability and efficiency of
Michal Michalec, Lukáš Daněk, Jan Foltýn, Petr Svoboda, Carsten Gachot, Martin Hartl, Ivan Křupka   +6 more
wiley   +1 more source

Nuclear localization sequence of MoHTR1, a Magnaporthe oryzae effector, for transcriptional reprogramming of immunity genes in rice. [PDF]

Nat Commun
Lim YJ, Yoon YJ, Lee H, Choi G, Kim S, Ko J, Kim JH, Kim KT, Lee YH.   +8 more
europepmc   +1 more source

A Perspective on Powder Metallurgy and Additive Manufacturing of High‐Nitrogen Alloyed Stainless Steels

Advanced Engineering Materials, EarlyView.
This perspective article explores an innovative powder metallurgical approach to producing high‐nitrogen steels by utilizing a mixture of stainless steel and Si3N4. This mixture undergoes hot isostatic pressing followed by direct quenching. The article also examines adapting this method to laser powder bed fusion (PBF‐LB/M) to overcome nitrogen ...
Louis Becker, Felix Radtke, Jonathan Lentz, Simone Herzog, Christoph Broeckmann, Sebastian Weber   +5 more
wiley   +1 more source