Results 331 to 340 of about 701,488 (371)

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

Science, 1995
Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear envelope followed by translocation through the nuclear pore. A recombinant human protein, hSRP1 alpha, bound in vitro specifically and directly to substrates containing either a simple or bipartite ...
Weis, Karsten, Mattaj, Iain W., Lamond, Angus I.   +2 more
openaire   +4 more sources

Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate.

Bioconjugate chemistry, 2011
The nonviral vector with iodine-nuclear localization sequence (namely, NLS-I) targeting breast cancer cells was fabricated. Ternary complexes were formed via charge interactions among NLS-I peptides, PEI 1800, and DNA, and we investigated their cellular ...
Hui-Yuan Wang, Cao Li, Wen-jie Yi, Yun‐Xia Sun, Si-Xue Cheng, R. Zhuo, Xianzheng Zhang   +6 more
semanticscholar   +1 more source

Localization of AT-rich sequences at the nuclear matrix

Cell Biology International Reports, 1986
After culture with 3H-thymidine murine erythroleukemia cells with more sites of DNA attached to the nuclear matrix have more labeled thymidine in their matrix-bound DNA than in their total DNA than do cells with fewer attachment sites. This indicates that the average attachment site sequence is enriched in A + T base pairs.
openaire   +3 more sources

The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.

Biochemistry, 2008
The HIV p17 or matrix (MA) protein has long been implicated in the process of nuclear import of the HIV genome and thus the ability of the virus to infect nondividing cells such as macrophages.
A. Hearps, K. Wagstaff, S. Piller, D. Jans   +3 more
semanticscholar   +1 more source

Synthesis and Binding Properties of Oligonucleotides Carrying Nuclear Localization Sequences

Bioconjugate Chemistry, 1999
The synthesis of oligonucleotides carrying nuclear localization peptide sequences is described using two strategies: first, oligonucleotides carrying a thiol group at the 5' end were reacted with maleimido peptides; second, peptide and oligonucleotide were prepared stepwise on the same support, yielding oligonucleotide-3'-peptide conjugates.
Ramon Eritja, and Angela Bachi, ‡ Ester Saison-Behmoaras, Beatriz G. de la Torre, Fernando Albericio   +4 more
openaire   +3 more sources

A Nuclear Localization Sequence Endows Human Pancreatic Ribonuclease with Cytotoxic Activity [PDF]

Biochemistry, 2004
Some members of the ribonuclease superfamily, such as Onconase, are cytotoxic to cancer cells. This is not the case for human pancreatic ribonuclease. This lack of cytotoxicity is probably a result of the inhibition exerted by the cytosolic ribonuclease inhibitor once the protein has reached the cytosol.
Bosch, Montserrat, Benito, Antoni, Ribó, Marc, Puig, Teresa, Beaumelle, Bruno, Vilanova, Maria   +5 more
openaire   +3 more sources

The yeast nucleoporin Nsp1 binds nuclear localization sequences in vitro

Biochemistry and Cell Biology, 1996
Facilitated transport of proteins into the nucleus requires nuclear localization sequences (NLSs) be present in the protein destined for the nucleus. The specific binding of NLSs by components of the nuclear transport apparatus is essential for these targeting reactions.
Ursula Stochaj, Werner Barth
openaire   +3 more sources

Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.

American Journal of Physiology - Cell Physiology, 2007
Angiotensin II (ANG II) type 1 (AT(1)) receptors, similar to other G protein-coupled receptors, undergo desensitization and internalization, and potentially nuclear localization, subsequent to agonist interaction.
T. Morinelli, J. Raymond, A. Baldys, Qing Yang, Mi‐Hye Lee, L. Luttrell, M. Ullian   +6 more
semanticscholar   +1 more source

Ultrastructural Analysis of the Nuclear Localization Sequences on Influenza A Ribonucleoprotein Complexes

Journal of Molecular Biology, 2007
The influenza A genome consists of eight single-stranded RNA molecules, each associated with an oligomeric core of the structural protein, nucleoprotein, to form a distinct viral ribonucleoprotein (vRNP) complex. vRNPs are the entities responsible for the transcription and replication of the influenza viral RNAs in the nuclei of host cells.
Lindsay L. Weaver, Nelly Panté, Winco W.H. Wu   +2 more
openaire   +3 more sources

Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis.

Biochemical and Biophysical Research Communications - BBRC, 2001
Human Scythe (also known as BAT3) has been implicated in the control of apoptosis and regulating heat shock protein (HSP) 70 activity. We have attempted to further characterize the role of human Scythe in HeLa cells by studying the cellular localization ...
Steve Manchen, A. Hubberstey
semanticscholar   +1 more source