Results 341 to 350 of about 701,488 (371)

The Immunoreactive Region in a Novel Autoantigen Contains a Nuclear Localization Sequence

Clinical Immunology and Immunopathology, 1994
Antibodies in the serum of patients with autoimmune diseases have been used to identify human autoantigens. Because autoantibodies often recognize active sites within corresponding protein antigens, autoantibodies have facilitated the functional characterization of these polypeptides.
Daniel Bloch, Thomas Quertermous, Kenneth D. Bloch, Diana Rabkina   +3 more
openaire   +3 more sources

Antibodies against the SV40 large T antigen nuclear localization sequence

Archives of Biochemistry and Biophysics, 1991
Transport of large proteins into the nucleus requires both a nuclear localization signal (NLS) and exposure of that signal to components of the transport machinery. In this report, polyclonal and monoclonal antibodies were generated against the NLS of SV40 large T antigen.
Barbara Wolff, John A. Hanover, Emily Klima, Min Kyun Park   +3 more
openaire   +3 more sources

The Fluorinated and Chlorinated Nuclear Localization Sequence of the SV 40 T Antigen

Chemical Biology & Drug Design, 2008
Nuclear uptake of the simian virus (SV) 40 T antigen is triggered by a specific nuclear localization sequence. However, such a nuclear localization sequence is only poorly taken up by the cytoplasm of cells when administered to the culture medium.
Alexander Sturzu, Stefan Heckl
openaire   +3 more sources

Identification of sequence determinants of human nuclear dUTPase isoform localization

Experimental Cell Research, 2003
dUTP nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and is the central regulator of cellular dUTP pools. Nuclear (DUT-N) and mitochondrial (DUT-M) isoforms of the protein have been identified in humans and arise from the same gene by the alternative use of 5' exons.
Tinkelenberg, Beverly A, Fazzone, William, Lynch, Frank J, Ladner, Robert D   +3 more
openaire   +3 more sources

A novel transfecting peptide comprising a tetrameric nuclear localization sequence

Journal of Molecular Medicine, 2003
The transport of exogenous DNA into the nucleus of eukaryotic cells is a prerequisite for successful gene delivery. To favor nuclear transport we synthesized a tetramer of the nuclear localization signal (NLS) of the SV40 large T-antigen as a novel nonviral gene delivery vector.
James Lausier, Wolfgang Ritter, Dietrich Reinhardt, Carsten Rudolph, Christian Plank, Joseph Rosenecker, Daniela Zink   +6 more
openaire   +3 more sources

Identification of a nuclear localization sequence in the polyomavirus capsid protein VP2

Virology, 1992
A nuclear localization signal (NLS) has been identified in the C-terminal (Glu307-Glu-Asp-Gly-Pro-Gln-Lys-Lys-Lys-Arg-Arg-Leu318) amino acid sequence of the polyomavirus minor capsid protein VP2. The importance of this amino acid sequence for nuclear transport of newly synthesized VP2 was demonstrated by a genetic "subtractive" study using the ...
John N. Brady, Richard A. Consigli, John I. Haynes, Deching Chang   +3 more
openaire   +3 more sources

Characterization of a nuclear localization sequence in the polyomavirus capsid protein VP1

Virology, 1991
Expression of VP1-beta-galactosidase fusion proteins in the yeast Saccharomyces cerevisiae was used to identify a domain of the polyomavirus VP1 capsid protein which targets this protein to the nucleus. Fusion of the first 17 amino acids of VP1 to beta-galactosidase was sufficient for nuclear localization, whereas fusion of the first 12 amino acids ...
Robert L. Garcea, Robert B. Moreland
openaire   +3 more sources

14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.

Biochemistry, 2005
The 14-3-3 proteins are a family of regulatory signaling molecules that interact with other proteins in a phosphorylation-dependent manner. 14-3-3 proteins are thought to play a direct role in the regulation of subcellular localization of FoxO forkhead ...
V. Obsilova, J. Večeř, P. Heřman, Anna Pabianova, M. Sulc, J. Teisinger, E. Bouřa, T. Obsil   +7 more
semanticscholar   +1 more source

Specific Nuclear Localization Sequence Binding to Plant Nuclei

1994
The import of proteins into the nucleus is mediated by nuclear localization sequences (NLSs), which are short polypeptide regions having a high content of basic amino acids (for reviews, see Roberts, 1989; Garcia-Bustos et al., 1991; Raikhel, 1992).
Valentina Kovaleva, Natasha V. Raikhel, Glenn R. Hicks   +2 more
openaire   +2 more sources

Nuclear translocation of IFN-gamma is an intrinsic requirement for its biologic activity and can be driven by a heterologous nuclear localization sequence.

Journal of Interferon and Cytokine Research, 2001
We have previously identified a nuclear localization sequence (NLS) in interferon-gamma (IFN-gamma). This NLS functions intracellularly by forming a complex with its transcription factor Stat1alpha and the nuclear importer of Stat1alpha, the importin ...
P. Subramaniam, Marino M. Green, Joseph Larkin, Barbara A. Torres, Howard M. Johnson   +4 more
semanticscholar   +1 more source