Results 351 to 360 of about 1,162,025 (392)

Sequence Determinants for hnRNP I Protein Nuclear Localization

Experimental Cell Research, 1997
hnRNP I, also referred to as polypyrimidine tract binding protein, is one of the proteins associated with nascent pre-mRNA in the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. As for all karyophilic proteins, the nuclear import of hnRNP proteins requires specific sequence determinants that in many instances differ from the canonical import
Romanelli M. G., Weighardt F., Biamonti G., Riva S., Morandi C.   +4 more
openaire   +4 more sources

Centromere sequences localize to the nuclear halo of human spermatozoa

International Journal of Andrology, 1998
Chromatin is organized into a series of discrete nuclear matrix‐associated and non‐nuclear matrix‐associated domains. The non‐matrix‐associated domains consist of loops of DNA that are attached to the proteinaceous nuclear matrix by matrix‐associated regions (MARs). Although this organization is well characterized in somatic cells, comparatively little
Yuval Yaron, S. A. Krawetz, M. P. Johnson, J. A. Kramer, M. I. Evans, Saleh A.D. Ebrahim, K. Gyi   +6 more
openaire   +3 more sources

Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate.

Bioconjugate chemistry, 2011
The nonviral vector with iodine-nuclear localization sequence (namely, NLS-I) targeting breast cancer cells was fabricated. Ternary complexes were formed via charge interactions among NLS-I peptides, PEI 1800, and DNA, and we investigated their cellular ...
Hui-Yuan Wang, Cao Li, Wen-jie Yi, Yun‐Xia Sun, Si-Xue Cheng, R. Zhuo, Xianzheng Zhang   +6 more
semanticscholar   +1 more source

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

Science, 1995
Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear envelope followed by translocation through the nuclear pore. A recombinant human protein, hSRP1 alpha, bound in vitro specifically and directly to substrates containing either a simple or bipartite ...
Weis, Karsten, Mattaj, Iain W., Lamond, Angus I.   +2 more
openaire   +4 more sources

Localization of AT-rich sequences at the nuclear matrix

Cell Biology International Reports, 1986
After culture with 3H-thymidine murine erythroleukemia cells with more sites of DNA attached to the nuclear matrix have more labeled thymidine in their matrix-bound DNA than in their total DNA than do cells with fewer attachment sites. This indicates that the average attachment site sequence is enriched in A + T base pairs.
openaire   +3 more sources

The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.

Biochemistry, 2008
The HIV p17 or matrix (MA) protein has long been implicated in the process of nuclear import of the HIV genome and thus the ability of the virus to infect nondividing cells such as macrophages.
A. Hearps, K. Wagstaff, S. Piller, D. Jans   +3 more
semanticscholar   +1 more source

Synthesis and Binding Properties of Oligonucleotides Carrying Nuclear Localization Sequences

Bioconjugate Chemistry, 1999
The synthesis of oligonucleotides carrying nuclear localization peptide sequences is described using two strategies: first, oligonucleotides carrying a thiol group at the 5' end were reacted with maleimido peptides; second, peptide and oligonucleotide were prepared stepwise on the same support, yielding oligonucleotide-3'-peptide conjugates.
Ramon Eritja, and Angela Bachi, ‡ Ester Saison-Behmoaras, Beatriz G. de la Torre, Fernando Albericio   +4 more
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A Nuclear Localization Sequence Endows Human Pancreatic Ribonuclease with Cytotoxic Activity [PDF]

Biochemistry, 2004
Some members of the ribonuclease superfamily, such as Onconase, are cytotoxic to cancer cells. This is not the case for human pancreatic ribonuclease. This lack of cytotoxicity is probably a result of the inhibition exerted by the cytosolic ribonuclease inhibitor once the protein has reached the cytosol.
Bosch, Montserrat, Benito, Antoni, Ribó, Marc, Puig, Teresa, Beaumelle, Bruno, Vilanova, Maria   +5 more
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Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.

American Journal of Physiology - Cell Physiology, 2007
Angiotensin II (ANG II) type 1 (AT(1)) receptors, similar to other G protein-coupled receptors, undergo desensitization and internalization, and potentially nuclear localization, subsequent to agonist interaction.
T. Morinelli, J. Raymond, A. Baldys, Qing Yang, Mi‐Hye Lee, L. Luttrell, M. Ullian   +6 more
semanticscholar   +1 more source

The yeast nucleoporin Nsp1 binds nuclear localization sequences in vitro

Biochemistry and Cell Biology, 1996
Facilitated transport of proteins into the nucleus requires nuclear localization sequences (NLSs) be present in the protein destined for the nucleus. The specific binding of NLSs by components of the nuclear transport apparatus is essential for these targeting reactions.
Ursula Stochaj, Werner Barth
openaire   +3 more sources