Results 81 to 90 of about 929,541 (348)

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-α Using Oriented Peptide Library Screening*

Journal of Biological Chemistry, 2010
Importin-α is the nuclear import receptor that recognizes the classic monopartite and bipartite nuclear localization sequences (cNLSs), which contain one or two clusters of basic amino acids, respectively.
Sundy N. Y. Yang, A. Takeda, M. Fontes, Jonathan M. Harris, D. Jans, B. Kobe   +5 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells

Nature, 2017
Long noncoding RNAs (lncRNAs) are emerging as key parts of multiple cellular pathways, but their modes of action and how these are dictated by sequence remain unclear.
Yoav Lubelsky, I. Ulitsky
semanticscholar   +1 more source

Nuclear accumulation of Saccharomyces cerevisiae Mcm3 is dependent on its nuclear localization sequence [PDF]

Genes to Cells, 1997
Background:The proteins of the Mcm2‐7 family are required for the initiation of DNA replication. In Saccharomyces cerevisiae the nuclear envelope does not break down during the mitotic phase of the cell cycle. Large nuclear proteins, such as the Mcm proteins, which accumulate in the nucleus during specific portions of the cell cycle, must have ...
Young, Michael R., Suzuki, Katsunori, Yan, Hong, Gibson, Susan, Tye, Bik Kwoon   +4 more
openaire   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Prediction of nuclear proteins using nuclear translocation signals proposed by probabilistic latent semantic indexing

BMC Bioinformatics, 2012
Background Identification of subcellular localization in proteins is crucial to elucidate cellular processes and molecular functions in a cell. However, given a tremendous amount of sequence data generated in the post-genomic era, determining protein ...
Su Emily, Chang Jia-Ming, Cheng Cheng-Wei, Sung Ting-Yi, Hsu Wen-Lian   +4 more
doaj   +1 more source

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Journal of Translational Medicine, 2019
Background Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay between the stress response and the gene
Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani, Gabriella Guida   +12 more
doaj   +1 more source

A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. [PDF]

PLoS ONE, 2011
The ability to modulate gene expression in response to sensory experience is critical to the normal development and function of the nervous system. Calcium is a key activator of the signal transduction cascades that mediate the process of translating a ...
Meredith J Ezak, Denise M Ferkey
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

BMC Cell Biology, 2008
Background The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlled by protein-protein interactions.
Valovka Taras, Hassa Paul O, Altmeyer Matthias, Haenni Sandra S, Fey Monika, Hottiger Michael O   +5 more
doaj   +1 more source