Results 101 to 110 of about 345,890 (219)

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

Angewandte Chemie International Edition, Accepted Article.
Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di‐)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids to interact with the negatively charged phosphodiester groups via hydrogen bonds and salt bridges.
Jens Wöhnert, Konstantin Neissner, Elke Duchardt-Ferner, Christoph Wiedemann, Julian Kraus, Ute A. Hellmich   +5 more
wiley   +1 more source

Effects of ion type and concentration on the structure and aggregation of the amyloid peptide Aβ16−22$$ {\boldsymbol{\beta}}_{16-22} $$

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Among the various factors controlling the amyloid aggregation process, the influences of ions on the aggregation rate and the resulting structures are important aspects to consider, which can be studied by molecular simulations. There is a wide variety of protein force fields and ion models, raising the question of which model to use in such ...
Eva Smorodina, Batuhan Kav, Hebah Fatafta, Birgit Strodel   +3 more
wiley   +1 more source

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

Angewandte Chemie International Edition, Accepted Article.
Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologically active natural products. P.
Shuaibing Zhang, Ying Huang, Raed Nachawati, Philipp Huber, Grit Walther, Lucas Gregor, Ivan Vilotijević, Pierre Stallforth   +7 more
wiley   +1 more source

Entrapped Molecule‐Like Europium‐Oxide Clusters in Zinc Oxide with Nearly Unaffected Host Structure

Small, Volume 19, Issue 1, January 4, 2023., 2023
Eu‐oxide cluster inclusions in ZnO explain the almost retained ZnO unit‐cell dimensions observed upon doping with large, aliovalent Eu3+ ions. Abstract Nanocrystalline ZnO sponges doped with 5 mol% EuO1.5 are obtained by heating metal–salt complex based precursor pastes at 200–900 °C for 3 min.
Soham Mukherjee, Sarmad Naim Katea, Emille M. Rodrigues, Carlo. U. Segre, Eva Hemmer, Peter Broqvist, Håkan Rensmo, Gunnar Westin   +7 more
wiley   +1 more source

Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering

Angewandte Chemie International Edition, Accepted Article.
Cold‐adapted bidomain enzymes have the potential to foster industrial sustainability by reducing energy consumption and greenhouse gas emissions. Despite their allure, these benefits are unattainable as the molecular basis of cold adaptation remains elusive and there are no strategies to guide the acquisition of this behavior.
Zhongyue J. Yang, Ning Ding, Yaoyukun Jiang, Robbie Ge, Qianzhen Shao, Wook Shin, Xinchun Ran   +6 more
wiley   +1 more source

Axion‐Like Interactions and CFT in Topological Matter, Anomaly Sum Rules and the Faraday Effect

Advanced Physics Research, EarlyView.
This review investigates the connection between chiral anomalies and their manifestation in topological materials, using both perturbative methods based on ordinary quantum field theory and conformal field theory (CFT). It emphasizes the role of CFT in momentum space for parity‐odd correlation functions, and their reconstruction by the inclusion of a ...
Claudio Corianò, Mario Cretì, Stefano Lionetti, Dario Melle, Riccardo Tommasi   +4 more
wiley   +1 more source

Lipid dysmetabolism in ceruloplasmin‐deficient mice revealed both in vivo and ex vivo by MRI, MRS and NMR analyses

FEBS Open Bio
Ceruloplasmin (Cp) is a ferroxidase that plays a role in cellular iron homeostasis and is mainly expressed in the liver and secreted into the blood. Cp is also produced by adipose tissue, which releases it as an adipokine.
Valeria Mannella, Linda Chaabane, Tamara Canu, Alan Zanardi, Sara Raia, Antonio Conti, Barbara Ferrini, Andrea Caricasole, Giovanna Musco, Massimo Alessio   +9 more
doaj   +1 more source

New Trends in SERS Substrates With Micro‐ and Nanostructures: Materials, Substrates, Preparation, and Applications

Battery Energy, EarlyView.
In this review, the latest research progress in surface‐enhanced Raman scattering (SERS) is discussed comprehensively. It covers four main aspects of SERS technology: materials utilized, various types of SERS substrates, methods employed for their preparation, and recent applications explored in the field over the past few years.
Xiaoyu Tian, Bo Zhang, Lei Song, Jingwei Bao, Junsheng Yang, Liangbo Sun, Houchang Pei, Chunpeng Song   +7 more
wiley   +1 more source

Magnetic Field-dependent Isotope Effect Supports Radical Pair Mechanism in Tubulin Polymerization [PDF]

arXiv
Weak magnetic fields and isotopes have been shown to influence biological processes; however, the underlying mechanisms remain poorly understood, particularly because the corresponding interaction energies are far below thermal energies, making classical explanations challenging or impossible.
arxiv