Results 21 to 30 of about 345,890 (219)
Frontiers in Molecular Biosciences, 2021 Relaxation in nuclear magnetic resonance is a powerful method for obtaining spatially resolved, timescale-specific dynamics information about molecular systems. However, dynamics in biomolecular systems are generally too complex to be fully characterized
Kai Zumpfe, Albert A. Smith
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Phase coherent excitation of SABRE permits simultaneous hyperpolarization of multiple targets at high magnetic field [PDF]
, 2021 Hyperpolarization methods in magnetic resonance overcome sensitivity limitations, especially for low-{\gamma} nuclei such as 13C and 15N. Signal Amplification By Reversible Exchange (SABRE) and extended SABRE (X-SABRE) are efficient and low-cost methods for generating large polarizations on a variety of nuclei, but they most commonly use low magnetic ...
arxiv +1 more source
Dynamic nuclear polarization and spin-diffusion in non-conducting solids [PDF]
Appl. Magn. Reson. 34, 409-421 (2008), 2008 There has been much renewed interest in dynamic nuclear polarization (DNP), particularly in the context of solid state biomolecular NMR and more recently dissolution DNP techniques for liquids. This paper reviews the role of spin diffusion in polarizing nuclear spins and discusses the role of the spin diffusion barrier, before going on to discuss some ...
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Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?
Frontiers in Molecular Biosciences, 2022 Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected stages
Luca G. Mureddu, Geerten W. Vuister
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Conceptual-level workflow modeling of scientific experiments using NMR as a case study
BMC Bioinformatics, 2007 Background Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans in the process when intuition and human reasoning are required.
Gryk Michael R +2 more
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Tropical Animal Science Journal, 2021 The objectives of this study were to characterize and compare non-volatile polar metabolite profiles of bovine colostrum, collected within 1 h and at 72 h after parturition, from crossbred Holstein cows raised in northeastern Thailand.
S. Settachaimongkon +4 more
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170 Nanometer Nuclear Magnetic Resonance Imaging using Magnetic Resonance Force Microscopy [PDF]
J. Mag. Reson. 162, 336 (2003), 2002 We demonstrate one-dimensional nuclear magnetic resonance imaging of the semiconductor GaAs with 170 nanometer slice separation and resolve two regions of reduced nuclear spin polarization density separated by only 500 nanometers. This is achieved by force detection of the magnetic resonance, Magnetic Resonance Force Microscopy (MRFM), in combination ...
arxiv +1 more source
Molecular Dynamics Studies on the Buffalo Prion Protein [PDF]
Journal of biomolecular Structure & Dynamics 04/2016;
34(4):762-777, 2015 It was reported that buffalo is a low susceptibility species resisting to prion diseases, which are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of species. In molecular structures, TSE neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein, predominantly with
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Meridional composite pulses for low-field magnetic resonance [PDF]
, 2022 We discuss procedures for error-tolerant spin control in environments that permit transient, large-angle reorientation of magnetic bias field. Short sequences of pulsed, non-resonant magnetic field pulses in a laboratory-frame meridional plane are derived.
arxiv +1 more source
Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery
Molecules, 2017 Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health.
Do-Hee Kim, Sung-Min Kang, Bong-Jin Lee
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