Results 31 to 40 of about 19,734 (123)
Recent Advances in Solid-State Nuclear Magnetic Resonance Techniques to Quantify Biomolecular Dynamics [PDF]
Analytical Chemistry, 2013 The emergence of solid-state NMR (SSNMR) techniques over the last decade has greatly expanded the range of accessible biomolecules amenable to structural study.1-2 These methods were developed and first applied to a variety of microcrystalline model proteins including BPTI,3 SH3,4-5 ubiquitin,6-7 kaliotoxin,8 and GB1.9-11 These studies demonstrated ...
Eric D, Watt, Chad M, Rienstra
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Utility of methyl side chain probes for solution NMR studies of large proteins
Journal of Magnetic Resonance Open, 2023 Selective isotopic labeling of methyl side chain groups in proteins and other biomolecules, combined with advances in perdeuteration, new pulse sequences, and high field spectrometers with cryogenic probes, has revolutionized the field of solution ...
Andrew C. McShan
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BMC Chemistry, 2022 Nuclear Magnetic Resonance (NMR) spectroscopy is an indispensable technique for the structure elucidation of molecules and determination of their characteristic interactions.
Ali Yassin +4 more
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Journal of Hematology & Oncology, 2016 Despite the considerable progress in understanding the molecular bases of acute myeloid leukemia (AML), new tools to link disease biology to the unpredictable patient clinical course are still needed.
Matteo G. Carrabba +11 more
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17O NMR Spectroscopy: A Novel Probe for Characterizing Protein Structure and Folding
Biology, 2021 Oxygen is a key atom that maintains biomolecular structures, regulates various physiological processes, and mediates various biomolecular interactions. Oxygen-17 (17O), therefore, has been proposed as a useful probe that can provide detailed information ...
Srinivasan Muniyappan +3 more
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Frontiers in Molecular Biosciences, 2021 Relaxation in nuclear magnetic resonance is a powerful method for obtaining spatially resolved, timescale-specific dynamics information about molecular systems. However, dynamics in biomolecular systems are generally too complex to be fully characterized
Kai Zumpfe, Albert A. Smith
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Conceptual-level workflow modeling of scientific experiments using NMR as a case study
BMC Bioinformatics, 2007 Background Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans in the process when intuition and human reasoning are required.
Gryk Michael R +2 more
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Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery
Molecules, 2017 Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health.
Do-Hee Kim, Sung-Min Kang, Bong-Jin Lee
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Imaging Sequences for Hyperpolarized Solids
Molecules, 2020 Hyperpolarization is one of the approaches to enhance Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) signal by increasing the population difference between the nuclear spin states.
Xudong Lv +7 more
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Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?
Frontiers in Molecular Biosciences, 2022 Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected stages
Luca G. Mureddu, Geerten W. Vuister
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