Results 21 to 30 of about 49,014 (224)
Journal of Hematology & Oncology, 2016 Despite the considerable progress in understanding the molecular bases of acute myeloid leukemia (AML), new tools to link disease biology to the unpredictable patient clinical course are still needed.
Matteo G. Carrabba +11 more
doaj +1 more source
Developing a scoring function for NMR structure-based assignments using machine learning [PDF]
, 2010 Determining the assignment of signals received from the ex- periments (peaks) to speci_c nuclei of the target molecule in Nuclear Magnetic Resonance (NMR1) spectroscopy is an important challenge.
Apaydın, Mehmet Serkan +8 more
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17O NMR Spectroscopy: A Novel Probe for Characterizing Protein Structure and Folding
Biology, 2021 Oxygen is a key atom that maintains biomolecular structures, regulates various physiological processes, and mediates various biomolecular interactions. Oxygen-17 (17O), therefore, has been proposed as a useful probe that can provide detailed information ...
Srinivasan Muniyappan +3 more
doaj +1 more source
A Spectral-Scanning Nuclear Magnetic Resonance Imaging (MRI) Transceiver [PDF]
, 2009 An integrated spectral-scanning nuclear magnetic resonance imaging (MRI) transceiver is implemented in a 0.12 mum SiGe BiCMOS process. The MRI transmitter and receiver circuitry is designed specifically for small-scale surface MRI diagnostics ...
Babakhani, Aydin +2 more
core +1 more source
The development of biomolecular Raman optical activity spectroscopy [PDF]
, 2015 Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in right- and left-circularly polarized incident light or,
Barron, Laurence D.
core +1 more source
Frontiers in Molecular Biosciences, 2021 Relaxation in nuclear magnetic resonance is a powerful method for obtaining spatially resolved, timescale-specific dynamics information about molecular systems. However, dynamics in biomolecular systems are generally too complex to be fully characterized
Kai Zumpfe, Albert A. Smith
doaj +1 more source
Conceptual-level workflow modeling of scientific experiments using NMR as a case study
BMC Bioinformatics, 2007 Background Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans in the process when intuition and human reasoning are required.
Gryk Michael R +2 more
doaj +1 more source
Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function [PDF]
, 2017 Most cellular phenomena of interest to mammalian biology occur within the context of living tissues and organisms. However, today’s most advanced tools for observing and manipulating cellular function, based on fluorescent or light-controlled proteins ...
Davis, Hunter C. +6 more
core +1 more source
Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?
Frontiers in Molecular Biosciences, 2022 Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected stages
Luca G. Mureddu, Geerten W. Vuister
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Cryogen-Free dissolution Dynamic Nuclear Polarization polarizer operating at 3.35 T, 6.70 T and 10.1 T [PDF]
, 2018 Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, pre-clinical and clinical applications.
Ardenkjaer-Larsen, Jan Henrik +6 more
core +2 more sources