13C-Methyl isocyanide as an NMR probe for cytochrome P450 active site [PDF]
, 2009 The cytochromes P450 (CYPs) play a central role in many biologically important oxidation reactions, including the metabolism of drugs and other xenobiotic compounds.
Im, Sang-Choul +4 more
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Conceptual-level workflow modeling of scientific experiments using NMR as a case study
BMC Bioinformatics, 2007 Background Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans in the process when intuition and human reasoning are required.
Gryk Michael R +2 more
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Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?
Frontiers in Molecular Biosciences, 2022 Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected stages
Luca G. Mureddu, Geerten W. Vuister
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Tropical Animal Science Journal, 2021 The objectives of this study were to characterize and compare non-volatile polar metabolite profiles of bovine colostrum, collected within 1 h and at 72 h after parturition, from crossbred Holstein cows raised in northeastern Thailand.
S. Settachaimongkon +4 more
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Biological Magnetic Resonance Data Bank
Nucleic Acids Res., 2022 The Biological Magnetic Resonance Data Bank (BMRB, https://bmrb.io) is the international open data repository for biomolecular nuclear magnetic resonance (NMR) data.
J. Hoch +15 more
semanticscholar +1 more source
Partial (13)C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies [PDF]
, 2005 Analysis of the (13)C isotopic labeling patterns of nucleoside monophosphates (NMPs) extracted from Escherichia coli grown in a mixture of C-1 and C-2 glucose is presented. By comparing our results to previous observations on amino acids grown in similar
Kishore, Anita I. +2 more
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Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery
Molecules, 2017 Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health.
Do-Hee Kim, Sung-Min Kang, Bong-Jin Lee
doaj +1 more source
Accurate structural correlations from maximum likelihood superpositions. [PDF]
PLoS Computational Biology, 2008 The cores of globular proteins are densely packed, resulting in complicated networks of structural interactions. These interactions in turn give rise to dynamic structural correlations over a wide range of time scales.
Douglas L Theobald, Deborah S Wuttke
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A solution NMR view of lipidic cubic phases: Structure, dynamics, and beyond
BBA Advances, 2022 Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time scales, the ...
Thomas G Meikle +3 more
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The magnetic-resonance force microscope: a new tool for high-resolution, 3-D, subsurface scanned probe imaging [PDF]
, 2003 The magnetic-resonance force microscope (MRFM) is a novel scanned probe instrument which combines the three-dimensional (3-D) imaging capabilities of magnetic-resonance imaging with the high sensitivity and resolution of atomic-force microscopy.
Gosnell, Timothy R. +5 more
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