Results 121 to 130 of about 2,343,531 (340)
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Statistical mechanics of a polymer chain attached to the interface of a cone-shaped channel [PDF]
, 2017 A polymer chain confined in nano-scale geometry has been used to investigate the underlying mechanism of Nuclear Pore Complex (NPC), where transport of cargoes is directional. It was shown here that depending on the solvent quality (good or poor) across the channel, a polymer chain can be either inside or outside the channel or both.
arxiv +1 more source
Improving the Hole Picture: Towards a Consensus on the Mechanism of Nuclear Transport [PDF]
arXiv, 2023 Nuclear pore complexes (NPCs) mediate the exchange of materials between the nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and proteins into their required compartments. The static structure of the NPC is relatively well defined by recent cryo EM and other studies. The functional roles of dynamic components in the pore
arxiv
Mechanisms of nuclear pore complex assembly – two different ways of building one molecular machine
FEBS Letters, 2017 The nuclear pore complex (NPC) mediates all macromolecular transport across the nuclear envelope. In higher eukaryotes that have an open mitosis, NPCs assemble at two points in the cell cycle: during nuclear assembly in late mitosis and during nuclear ...
S. Otsuka, J. Ellenberg
semanticscholar +1 more source
Evolution: functional evolution of nuclear structure. [PDF]
, 2011 The evolution of the nucleus, the defining feature of eukaryotic cells, was long shrouded in speculation and mystery. There is now strong evidence that nuclear pore complexes (NPCs) and nuclear membranes coevolved with the endomembrane system, and that ...
Dawson, Scott C, Wilson, Katherine L
core
A study of the porosity of nuclear graphite using small-angle neutron scattering [PDF]
, 2013 Small angle neutron scattering (SANS) measures porosity in nuclear graphites, including both open pores, caused by escaping decomposition gases, and internal cracks (in coke particles) generated by anisotropic thermal contraction along the c-direction ...
Bale +17 more
core +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Nuclear pore interactions with the genome [PDF]
Current Opinion in Genetics & Development, 2014 Within the nucleus, chromatin is functionally organized into distinct nuclear compartments. The nuclear periphery, containing Nuclear Pore Complexes (NPCs), plays an important role in the spatial organization of chromatin and in transcriptional regulation.
Varun Sood, Jason H. Brickner
openaire +3 more sources
Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings
Nature Structural & Molecular Biology, 2017 The nuclear envelope has to be reformed after mitosis to create viable daughter cells with closed nuclei. How membrane sealing of DNA and assembly of nuclear pore complexes (NPCs) are achieved and coordinated is poorly understood.
S. Otsuka +9 more
semanticscholar +1 more source