Results 131 to 140 of about 2,343,531 (340)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells

open access: yesCell Reports, 2018
Summary: Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mESC ...
Benoit Souquet   +7 more
doaj  

Comparative study on pore size distribution in coal based on mercury intrusion-low temperature liquid nitrogen combined pore and nuclear magnetic resonance analysis

open access: yesMeikuang Anquan
The pore structure measurement in coal is commonly analyzed by mercury intrusion method, low temperature liquid nitrogen method and nuclear magnetic resonance method. Due to the different test methods, the results cannot be used uniformly, and the matrix
Nana LI, Huihu LIU, Shuxun SANG
doaj   +1 more source

Nuclear Pore Proteins in Regulation of Chromatin State

open access: yesCells, 2019
Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic transport. However, research efforts over the last decade have demonstrated that NPCs and their constituent nucleoporins (Nups) also interact with the genome and perform ...
Terra M. Kuhn, Maya Capelson
doaj   +1 more source

Diffusion Pore Imaging by Hyperpolarized Xenon-129 Nuclear Magnetic Resonance [PDF]

open access: yesarXiv, 2012
Nuclear magnetic resonance (NMR) diffusion measurements are widely used to derive parameters indirectly related to the microstructure of biological tissues and porous media. However, a direct imaging of cell or pore shapes and sizes would be of high interest.
arxiv  

Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex

open access: yesPLoS Biology, 2016
The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have ...
Samson O. Obado   +7 more
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Molecular genetics of oogenesis in Drosophila melanogaster [PDF]

open access: yesInvertebrate Survival Journal, 2004
Gonadal development requires complex differentiation programs leading to the production offunctional female and male gametes. Upon fertilization, while the male germ cell contributes to thenewly formed zygote only its genetic material, the female germ ...
S Gigliotti   +4 more
doaj  

Effect of inhomogeneous surface relaxivity, pore geometry and internal field gradient on NMR logging:exact and perturbative theories and numerical investigations [PDF]

open access: yesarXiv, 2009
Nuclear magnetic resonance is widely used as a probe of pore geometry and fluid composition in well logging. One of the critical assumptions often made is that the diffusion of fluid molecules is sufficiently fast to warrant the condition for direct mapping between the surface-enhanced relaxation rate and the pore geometry.
arxiv  

Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold

open access: yesScience, 2022
P. Fontana   +8 more
semanticscholar   +1 more source

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