Results 201 to 210 of about 326,922 (335)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Nuclear Pores

, 2001
openaire   +2 more sources

Unraveling dynamics of nuclear pore and chromatin via HS-AFM. [PDF]

Anat Sci Int
Nishide G, Wong RW.
europepmc   +1 more source

Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome

, 2021
Marcela Raı́ces, Maximiliano A. D’Angelo   +1 more
openalex   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Modeling Of The Nup84 Subcomplex Of The Nuclear Pore Complex

, 2014
Yi Shi, Javier Fernández-Martı́nez, Elina Tjioe, Riccardo Pellarin, Seung Joong Kim, Rosemary Williams, Dina Schneidman‐Duhovny, Michael P. Rout, Andrej Săli, Brian T. Chait   +9 more
openalex   +1 more source

The nuclear pore complex – structure and function at a glance [PDF]

, 2015
Greg Kabachinski, Thomas Schwartz
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Transcriptional condensates and the nuclear pore complex regulate gene expression and 3D genome architecture in response to stress. [PDF]

Biochem Soc Trans
Mohajan S, Gross DS.
europepmc   +1 more source

Roles of Nuclear Pores and Nucleo-cytoplasmic Trafficking in Plant Stress Responses [PDF]

, 2017
Yu Yang, Wei Wang, Zhaoqing Chu, Jian‐Kang Zhu, Huiming Zhang   +4 more
openalex   +1 more source