Results 171 to 180 of about 294,484 (344)

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Implications of a multiscale structure of the yeast nuclear pore complex. [PDF]

Mol Cell, 2023
Akey CW, Echeverria I, Ouch C, Nudelman I, Shi Y, Wang J, Chait BT, Sali A, Fernandez-Martinez J, Rout MP.   +9 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

HIV‐1 DNA Flap formation promotes uncoating of the pre‐integration complex at the nuclear pore [PDF]

, 2007
Nathalie J. Arhel, Sylvie Souquère, Sandie Munier, Philippe Souque, Stéphanie Guadagnini, Sandra Rutherford, Marie‐Christine Prévost, Terry D. Allen, Pierre Charneau   +8 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

The role of phase separation for RNA and protein transport through the nuclear pore complex. [PDF]

J Exp Bot
Ejike JO, Davis GV, Restrepo-Escobar A, Dalal A, Nakamura M, Frommer WB, Schladt TM.   +6 more
europepmc   +1 more source

Herpesvirus Capsid Association with the Nuclear Pore Complex and Viral DNA Release Involve the Nucleoporin CAN/Nup214 and the Capsid Protein pUL25

, 2009
David Pasdeloup, Danielle Blondel, Anabela Isidro, Frazer J. Rixon   +3 more
openalex   +1 more source

Preservation of Nuclear Envelope and Pore Complex Dynamics using High Pressure Freezing and Cryo-Field Emission SEM. [PDF]

, 2003
T. D. Allen, M. K. Hughes, Sandra Rutherford, Stephen Murray, Steve Bagley, Елена Киселева, Martin W. Goldberg   +6 more
openalex   +1 more source

The nuclear pore complex as an entropic gate: theory and simulation [PDF]

, 2020
Mike Castellano, Steffen Wolf, Thorsten Koslowski   +2 more
openalex   +1 more source

The nuclear pore complex.

Genome biology, 2002
Nuclear pore complexes, the conduits for information exchange between the nucleus and cytoplasm, appear broadly similar in eukaryotes from yeast to human. Precisely how nuclear pore complexes regulate macromolecular and ionic traffic remains unknown, but recent advances in the identification and characterization of components of the complex by ...
openaire   +1 more source