Results 181 to 190 of about 623,335 (318)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Structure and Function of the Nuclear Pore Complex. [PDF]

Cold Spring Harb Perspect Biol, 2022
Petrovic S, Mobbs GW, Bley CJ, Nie S, Patke A, Hoelz A.   +5 more
europepmc   +1 more source

The Fractal Blueprint: Soil Pores, Symmetry, and Climate Mitigation [PDF]

arXiv
Soil is a critical component of terrestrial ecosystems, directly influencing global biogeochemical cycles. Despite its importance, the complex architecture of soil pores and their impact on greenhouse gas emissions remain poorly understood. This perspective aims to address this gap by applying discrete symmetry and symmetry-breaking concepts through ...
arxiv  

Essential Roles forCaenorhabditis elegansLamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes [PDF]

, 2000
Jun Liu, Tom Rolef Ben-Shahar, Dieter Riemer, Millet Treinin, P. Spann, Klaus Weber, Andrew Fire, Yosef Gruenbaum   +7 more
openalex   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Nuclear Pore-Targeting Complex and Its Role on Nuclear Protein Transport.

, 1996
Yoshihiro Yoneda
openalex   +2 more sources

The nuclear pore complex: mediator of translocation between nucleus and cytoplasm [PDF]

, 2000
Terence Allen, J. M. Cronshaw, Steve Bagley, Елена Киселева, Martin W. Goldberg   +4 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

The Yeast Nuclear Pore Complex [PDF]

, 2000
Michael P. Rout, John D. Aitchison, Adisetyantari Suprapto, Kelly Hjertaas, Yingming Zhao, Brian T. Chait   +5 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source