Results 301 to 310 of about 294,484 (344)

Nuclear pore complexes feel the strain

Molecular Cell, 2021
A cryo-electron tomography structure of the human nuclear pore complex captured in cellulo by Schuller, Wojtynek et al. reveals that nuclear envelope tension expands the central transport channel and imposes asymmetry in the pore membrane.
C Patrick, Lusk, Megan C, King
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Pore relations: nuclear pore complexes and nucleocytoplasmic exchange

Essays in Biochemistry, 2000
NPCs are the sole sites of exchange between the nucleus and cytoplasm. A large family of transport factors carry cargo between the nucleus and cytoplasm through the NPC. The NPC is a huge symmetric octagonal structure comprised of dozens of NUPs. NUPs make many contacts with surrounding structures, including the NE, the cytoplasm and nuclear interior ...
M P, Rout, J D, Aitchison
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Poring over chromosomes: mitotic nuclear pore complex segregation

Current Opinion in Cell Biology, 2019
Eukaryotic cells rely on flux of macromolecules between the nucleus and the cytoplasm for growth and survival. Bidirectional transport is achieved through Nuclear Pore Complexes (NPCs) embedded in the Nuclear Envelope (NE). NPC proteins perform other cellular functions during mitosis, chromatin organization, DNA repair and gene regulation ...
Subbulakshmi, Suresh, Stephen A, Osmani
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Nuclear Pore Complexes

2010
Nuclear pore complexes (NPCs) are large macromolecular assemblies with an estimated mass of about 125 million Dalton. Depending on the activity of a cell, the number of NPCs varies but is usually around 3000–4000 per nucleus. NPCs are sites of bidirectional transport.
Margit Pavelka, Jürgen Roth
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Selective autophagy degrades nuclear pore complexes

Nature Cell Biology, 2020
Nuclear pore complexes (NPCs) are very large proteinaceous assemblies that consist of more than 500 individual proteins1,2. NPCs are essential for nucleocytoplasmic transport of different cellular components, and disruption of the integrity of NPCs has been linked to aging, cancer and neurodegenerative diseases3-7.
Chia-Wei Lee, Florian Wilfling, Paolo Ronchi, Matteo Allegretti, Shyamal Mosalaganti, Stefan Jentsch, Martin Beck, Boris Pfander   +7 more
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Ran alters nuclear pore complex conformation

Journal of Molecular Biology, 2000
Transport across the nuclear membranes occurs through the nuclear pore complex (NPC), and is mediated by soluble transport factors including Ran, a small GTPase that is generally GDP-bound during import and GTP-bound for export. The dynamic nature of the NPC structure suggests a possible active role for it in driving translocation.
Goldberg, MW, Rutherford, SA, Hughes, M, Cotter, LA, Bagley, S, Kiseleva, E, Allen, TD, Clarke, PR   +7 more
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RanGTP mediates nuclear pore complex assembly

Nature, 2003
In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm, assemble into the reforming nuclear envelope in a sequential process involving association of a subset of NPC proteins, nucleoporins, with chromatin followed by the ...
Tobias C, Walther, Peter, Askjaer, Marc, Gentzel, Anja, Habermann, Gareth, Griffiths, Matthias, Wilm, Iain W, Mattaj, Martin, Hetzer   +7 more
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Nuclear pore complexes: Round the bend?

Nature Cell Biology, 2005
Nuclear pore complexes intuitively seem functionally analogous to transmembrane channels. Recent bioinformatic analysis, however, suggests a quite different evolutionary relationship: one between nuclear pore complexes and vesicle coat components. This has led to the provocative hypothesis that these distinct structures share a common role in bending ...
Wolfram, Antonin, Iain W, Mattaj
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The nuclear pore complex up close

Current Opinion in Cell Biology, 2006
Transport between the nucleus and cytoplasm is mediated by nuclear pore complexes (NPCs), perforations in the double-membrane of the nuclear envelope. NPCs are huge protein assemblies made up of distinct subcomplexes. The complex modular nature of the NPC and limitations in the current experimental approaches render the analysis of NPCs and ...
Lim, R. Y. H., Fahrenkrog, B.
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Getting across the nuclear pore complex

Trends in Cell Biology, 1999
The nuclear pore complex (NPC) connects the cytoplasm and nucleus through the nuclear envelope and serves as the pipeline for moving material between the two compartments. Macromolecules that move through the NPC range in size from the very small (for example, ions and ATP) to the very large (for example, ribonucleoprotein particle complexes).
B, Talcott, M S, Moore
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