Results 211 to 220 of about 97,972 (258)

The role of the nucleus in the control of mitochondrial precursor proteins in yeast. [PDF]

Protein Sci
Ritzenhofen K, Rossi S, Mogk A, den Brave F.   +3 more
europepmc   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and impairs gemcitabine response in pancreatic cancer. [PDF]

Cell Death Dis
Sun H, Yang C, Du J, Xu C, Chen Y, Chen J, Yue N, Gong R, Yang Z.   +8 more
europepmc   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

TRPV6-Mediated Ca²⁺ Signaling in Pancreatic Ductal Adenocarcinoma: From Cellular Physiology to Therapeutic Opportunities. [PDF]

Cancers (Basel)
Yosef B, Venglovecz V.
europepmc   +1 more source

NUP1/NUP136 is essential for obligatory crossover formation during meiosis in Arabidopsis. [PDF]

Genetics
Fernández-Jiménez N, Varas J, Martínez-García M, Santos JL, Pradillo M.   +4 more
europepmc   +1 more source

NUP205 Stabilized YAP1 Protein to Stimulate Growth of Hepatocellular Carcinoma Cells in vitro and in vivo. [PDF]

J Hepatocell Carcinoma
Deng H, Yu S, Zhang J, Hou Y, Yang M, Yuan S, Tu Q, Wang M.   +7 more
europepmc   +1 more source

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion. [PDF]

Nat Commun
Lin J, Agote-Aran A, Liao Y, Cloarec M, Andronov L, Schoch RL, Ronchi P, Cochard V, Zhu R, Grandgirard E, Liu X, Lemée MV, Kleiss C, Golzio C, Ruff M, Chevreux G, Schwab Y, Klaholz BP, Sumara I.   +18 more
europepmc   +1 more source

Structural dynamics of the midnolin-proteasome during ubiquitin-independent substrate turnover. [PDF]

Nat Commun
Zhu C, Qin L, Dai Z, Zuo P, Yang A, Zhong L, Lin Z, Liang L.   +7 more
europepmc   +1 more source