Results 51 to 60 of about 64,864 (311)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

New technical solutions for the design of NPP passive safety systems [PDF]

Nuclear Energy and Technology
The paper describes the new principle of passive NPP safety systems designing, in which the natural circulation of working fluid or gas is replaced by forced circulation in order to increase it’s capacity.
Sergey L. Soloviev, Denis G. Zaryugin, Sergey G. Kalyakin, Sergey T. Leskin, Dmitry S. Soloviev   +4 more
doaj   +3 more sources

Autonomous Thermosiphon System of Passive Residual Heat Removal from the Primary Circuit of the Reactor Plant: Features of Operation, Characteristics and Basic Advantages

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2023
An autonomous system of passive removal of residual heat (PRRHS) of a reactor installation with VVER designed to ensure the safety of nuclear power plants in an accident with complete long-term blackout is considered.
I. I Sviridenko, D. V. Shevelyov
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Owners of Nuclear Power Plants [PDF]

, 2000
Commercial nuclear power plants in this country can be owned by a number of separate entities, each with varying ownership proportions. Each of these owners may, in turn, have a parent/subsidiary relationship to other companies. In addition, the operator
Reid, R. L.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Nuclear Power: a Hedge against Uncertain Gas and Carbon Prices?

, 2006
High fossil fuel prices have rekindled interest in nuclear power. This paper identifies specific nuclear characteristics making it unattractive to merchant generators in liberalised electricity markets, and argues that non-fossil fuel technologies have ...
Stephen Connors, William J. Nuttall, Fabien A. Roques , Richard de Neufville, David M. Newbery   +4 more
core   +1 more source

Magnesium potassium phosphate cements to immobilize radioactive concrete wastes generated by decommissioning of nuclear power plants

, 2021
This paper evaluates the efficacy of magnesium potassium phosphate cements (MKPCs) as waste forms for the solidification of radioactive concrete powder wastes produced by the decommissioning of nuclear power plants. MKPC specimens that contained up to 50
Heo, J., Um, W., Pyo, J.-Y.
core   +1 more source

Analysis of long-term monitoring data around the area of localization of nuclear-hazardous clusters in the "Shelter" Object [PDF]

Ядерна фізика та енергетика
The results of a comprehensive analysis of neutron flux density (NFD), gamma-radiation exposure dose rate (GDR), dynamics of concrete temperature and air humidity in the vicinity of nuclearly hazardous fuel-containing material cluster (NHC) in room 305/2
O. V. Mykhailov, M. V. Saveliev, A. O. Doroshenko   +2 more
doaj   +1 more source