Results 61 to 70 of about 64,864 (311)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Owners of nuclear power plants [PDF]

, 1996
Commercial nuclear power plants in this country can be owned by a number of separate entities, each with varying ownership proportions. Each of these owners may, in turn, have a parent/subsidiary relationship to other companies. In addition, the operator
Hudson, C.R., White, V.S.
core   +1 more source

Results of analysis of temperature monitoring data around the nuclearly hazardous cluster of fuel-containing materials in the sub-reactor room 305/2 of the "Shelter" object, inside and outside the new safe confinement [PDF]

Ядерна фізика та енергетика
The results of the analysis of temperature monitoring data were obtained using the information and measuring system (IMS) "Finish" (1991 - 2015) and expert research system, new safe confinement (NSC) integrated control system in the main volume (MV ...
O. V. Mykhailov, A. O. Doroshenko, M. V. Saveliev   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hedonic Valuation of the Perceived Risks of Nuclear Power Plants [PDF]

, 2015
h i g h l i g h t s • 2011 Fukushima accident increased public awareness of risks of nuclear power plants. • Accident is used for quasi-experimental hedonic valuation of such risks. • Rents near nuclear power plants in Switzerland decreased by 2.3% after
Boes, Stefan, Wüthrich, Kaspar, Stefan Boes, Kaspar Wüthrich, Stephan Nüesch, Nüsch, Stephan   +5 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Short-Term Electrical Load Forecasting Based on XGBoost Model

Energies
Forecasting electricity consumption is one of the most important scientific and practical tasks in the field of electric power engineering. The forecast accuracy directly impacts the operational efficiency of the entire power system and the performance ...
Hristo Ivanov Beloev, Stanislav Radikovich Saitov, Antonina Andreevna Filimonova, Natalia Dmitrievna Chichirova, Oleg Evgenievich Babikov, Iliya Krastev Iliev   +5 more
doaj   +1 more source

Analysis of scenarios for transforming the object "Ukryttya" into an environmentally safe system by the method of multicriteria optimization [PDF]

Ядерна фізика та енергетика
Based on the criteria for comparative analysis of scenarios grouped into factors, the value of scenarios was determined using the multicriteria optimization methodology.
I. S. Skiter, V. V. Derenhovskyi
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source