Results 61 to 70 of about 372,244 (310)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Short-Term Electrical Load Forecasting Based on XGBoost Model

Energies
Forecasting electricity consumption is one of the most important scientific and practical tasks in the field of electric power engineering. The forecast accuracy directly impacts the operational efficiency of the entire power system and the performance ...
Hristo Ivanov Beloev, Stanislav Radikovich Saitov, Antonina Andreevna Filimonova, Natalia Dmitrievna Chichirova, Oleg Evgenievich Babikov, Iliya Krastev Iliev   +5 more
doaj   +1 more source

Analysis of scenarios for transforming the object "Ukryttya" into an environmentally safe system by the method of multicriteria optimization [PDF]

Ядерна фізика та енергетика
Based on the criteria for comparative analysis of scenarios grouped into factors, the value of scenarios was determined using the multicriteria optimization methodology.
I. S. Skiter, V. V. Derenhovskyi
doaj   +1 more source

Pathways towards the nuclear revival in Finland, France, and the UK [PDF]

, 2010
Nuclear power is undergoing a revival in a number of countries of both developed and developing world, and is increasingly presented as a solution to the problems of climate change and energy security.
Lehtonen, Markku, Martiskainen, Mari
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Prediction of Pipe Failure Rate in Heating Networks Using Machine Learning Methods

Energies
The correct prediction of heating network pipeline failure rates can increase the reliability of the heat supply to consumers in the cold season. However, due to the large number of factors affecting the corrosion of underground steel pipelines, it is ...
Hristo Ivanov Beloev, Stanislav Radikovich Saitov, Antonina Andreevna Filimonova, Natalia Dmitrievna Chichirova, Oleg Evgenievich Babikov, Iliya Krastev Iliev   +5 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Radioprotective influence on mice DNA of biopolymer complexes from tinder Fomes Fomentarius under ionizing radiation in small doses [PDF]

Ядерна фізика та енергетика, 2014
The effects of similar doses of the values of common external irradiation (0,19 Gy/4hours and 0,24 Gy/6 months) at single-strand DNA breaks and the level of the hydrogen bonds in this molecule in different cell types (lymphocytes, hepatocytes and ...
O. F. Seniuk, V. O. Kovalev, L. A. Palamar, M. I. Krul, L. F. Gorovoj   +4 more
doaj