Results 61 to 70 of about 40,288 (260)

New technical solutions for the design of NPP passive safety systems [PDF]

Nuclear Energy and Technology
The paper describes the new principle of passive NPP safety systems designing, in which the natural circulation of working fluid or gas is replaced by forced circulation in order to increase it’s capacity.
Sergey L. Soloviev, Denis G. Zaryugin, Sergey G. Kalyakin, Sergey T. Leskin, Dmitry S. Soloviev   +4 more
doaj   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Analysis of long-term monitoring data around the area of localization of nuclear-hazardous clusters in the "Shelter" Object [PDF]

Ядерна фізика та енергетика
The results of a comprehensive analysis of neutron flux density (NFD), gamma-radiation exposure dose rate (GDR), dynamics of concrete temperature and air humidity in the vicinity of nuclearly hazardous fuel-containing material cluster (NHC) in room 305/2
O. V. Mykhailov, M. V. Saveliev, A. O. Doroshenko   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Short-Term Electrical Load Forecasting Based on XGBoost Model

Energies
Forecasting electricity consumption is one of the most important scientific and practical tasks in the field of electric power engineering. The forecast accuracy directly impacts the operational efficiency of the entire power system and the performance ...
Hristo Ivanov Beloev, Stanislav Radikovich Saitov, Antonina Andreevna Filimonova, Natalia Dmitrievna Chichirova, Oleg Evgenievich Babikov, Iliya Krastev Iliev   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Results of analysis of temperature monitoring data around the nuclearly hazardous cluster of fuel-containing materials in the sub-reactor room 305/2 of the "Shelter" object, inside and outside the new safe confinement [PDF]

Ядерна фізика та енергетика
The results of the analysis of temperature monitoring data were obtained using the information and measuring system (IMS) "Finish" (1991 - 2015) and expert research system, new safe confinement (NSC) integrated control system in the main volume (MV ...
O. V. Mykhailov, A. O. Doroshenko, M. V. Saveliev   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Prediction of Pipe Failure Rate in Heating Networks Using Machine Learning Methods

Energies
The correct prediction of heating network pipeline failure rates can increase the reliability of the heat supply to consumers in the cold season. However, due to the large number of factors affecting the corrosion of underground steel pipelines, it is ...
Hristo Ivanov Beloev, Stanislav Radikovich Saitov, Antonina Andreevna Filimonova, Natalia Dmitrievna Chichirova, Oleg Evgenievich Babikov, Iliya Krastev Iliev   +5 more
doaj   +1 more source