Results 201 to 210 of about 8,751,128 (381)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects. [PDF]

Blood Adv, 2023
Li S, Fu J, Walker CJ, Yang J, Bhutani D, Chakraborty R, Mamillapalli N, Mapara MY, Landesman Y, Lentzsch S.   +9 more
europepmc   +1 more source

The complete amino acid sequence of the basic nuclear protein of bull spermatozoa [PDF]

, 1972
J.P. Coelingh, C.H. Monfoort, Thomas H. Rozijn, J.A. Gevers Leuven, Roelof Schiphof, Elizabeth P. Steyn-Parvé, G Braunitzer, B Schrank, A Ruhfus   +8 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein

Neurobiology of Disease, 2005
Nuclear aggregates of polyglutamine (polyQ)-expanded proteins are associated with a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxias (SCAs).
Lianwu Fu, Ya-sheng Gao, Elizabeth Sztul
doaj  

Nuclear protein-1 is the common link for pathways activated by aging and obesity in chondrocytes: A potential therapeutic target for osteoarthritis. [PDF]

FASEB J, 2023
Tan L, Armstrong AR, Rosas S, Patel CM, Vander Wiele SS, Willey JS, Carlson CS, Yammani RR.   +7 more
europepmc   +1 more source

Nuclear Dependency of Chloroplast Proteins in Acetabularia [PDF]

, 1972
Klaus Apel, Hans‐Georg Schweiger
openalex   +1 more source

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

Molecular and Cellular Biology, 1995
M. Ohtsubo, A. Theodoras, J. Schumacher, James M. Roberts, M. Pagano   +4 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source