Results 111 to 120 of about 5,069,870 (397)

Steroid receptor coactivators in Treg and Th17 cell biology and function

Frontiers in Immunology
Steroid receptor coactivators (SRCs) are master regulators of transcription that play key roles in human physiology and pathology. SRCs are particularly important for the regulation of the immune system with major roles in lymphocyte fate determination ...
Yosi Gilad, Yosi Gilad, Ortal Shimon, Ortal Shimon, Sang Jun Han, Sang Jun Han, Sang Jun Han, David M. Lonard, David M. Lonard, David M. Lonard, Bert W. O’Malley, Bert W. O’Malley, Bert W. O’Malley   +12 more
doaj   +1 more source

Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 [PDF]

, 2016
Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane- associated receptor, which has been discovered as the ...
Altieri, Fabio, Cervoni, Laura, Chichiarelli, Silvia, Eufemi, Margherita, Gaucci, Elisa, Grillo, Caterina, Nittari, Giulio, Raimondo, Domenico   +7 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)-α Pathway

Marine Drugs, 2019
Five new ergostanes, penicisteroids D−H (1−5), were isolated from the liquid culture of the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, along with 27 known compounds. The structures of the new steroids were established mainly
Chun-Lan Xie, Duo Zhang, Jin-Mei Xia, Chao-Chao Hu, Ting Lin, Yu-Kun Lin, Guang-Hui Wang, Wen-Jing Tian, Zeng-Peng Li, Xiao-Kun Zhang, Xian-Wen Yang, Hai-Feng Chen   +11 more
doaj   +1 more source

Reconstructing the TIR side of the Myddosome: a paradigm for TIR-TIR interactions? [PDF]

, 2015
Members of the Toll-like receptor and interleukin-1 (IL-1) receptor families all signal via Toll/IL-1R (TIR) domain-driven assemblies with adaptors such as MyD88.
Bovijn, Celia, Burg, Elianne, Pauwels, Ewald, Peelman, Frank, Ruyssinck, Elien, Tavernier, Jan, Van Acker, Tim, Vyncke, Laurens   +7 more
core   +2 more sources

Supplementary Fig. S1 from 1,1-Bis(3′-indolyl)-1-(<i>p</i>-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

, 2023
Teruo Inamoto, Sabitha Papineni, Sudhakar Chintharlapalli, Sung‐Dae Cho, Stephen Safe, Ashish M. Kamat   +5 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]

, 2013
Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor

Nature Communications
The histamine H4 receptor (H4R) plays key role in immune cell function and is a highly valued target for treating allergic and inflammatory diseases. However, structural information of H4R remains elusive.
Ruixue Xia, Shuang Shi, Zhenmei Xu, Henry F. Vischer, Albert D. Windhorst, Yu Qian, Yaning Duan, Jiale Liang, Kai Chen, Anqi Zhang, Changyou Guo, Rob Leurs, Yuanzheng He   +12 more
doaj   +1 more source