Results 161 to 170 of about 5,069,870 (397)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Retinoid X Receptor Regulates Nur77/Thyroid Hormone Receptor 3-Dependent Apoptosis by Modulating Its Nuclear Export and Mitochondrial Targeting

, 2004
Xihua Cao, Wen Liu, Feng Lin, Hui Li, Siva K. Kolluri, Bingzhen Lin, Hyun‐Ju An, Marcia I. Dawson, Xiao-kun Zhang   +8 more
openalex   +1 more source

The Calcium Signaling Pathway Regulates Leydig Cell Steroidogenesis through a Transcriptional Cascade Involving the Nuclear Receptor NR4A1 and the Steroidogenic Acute Regulatory Protein [PDF]

, 2012
Houssein S. Abdou, Gabrielle Villeneuve, Jacques Tremblay   +2 more
openalex   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors [PDF]

, 2021
S P H Alexander, John A. Cidlowski, Eamonn Kelly, Alistair Mathie, John A. Peters, Emma L. Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A. Davies, Laurel A. Coons, Peter J. Fuller, Kenneth S. Korach, Morag J. Young   +15 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Cell, 2002
Nicolas Preitner, F. Damiola, L. Lopez-Molina, J. Zakany, D. Duboule, U. Albrecht, U. Schibler   +6 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Association between Molecular Initiating Events and Drug-Induced Hiccups

Pharmaceuticals
Hiccups can significantly reduce the quality of life of patients and can occur as a drug side effect. Previous reports have revealed sex-specific differences in the incidence of drug-induced hiccups.
Ryuichiro Hosoya, Reiko Ishii-Nozawa, Tomoko Terajima, Hajime Kagaya, Yoshihiro Uesawa   +4 more
doaj   +1 more source

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression [PDF]

, 2016
Sandra M. Lopez, Alexander I. Agoulnik, Manqi Zhang, L. E. Peterson, Egla Suarez, Gregory A. Gandarillas, Anna Frolov, Rile Li, Kimal Rajapakshe, Christian Coarfa, Michael Ittmann, Nancy L. Weigel, Irina U. Agoulnik   +12 more
openalex   +1 more source

Maturing of the nuclear receptor family.

Journal of Clinical Investigation, 2017
M. Lazar
semanticscholar   +1 more source