Results 171 to 180 of about 5,069,870 (397)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Impact of Neonatal Activation of Nuclear Receptor CAR ( Nr 1 i 3) on Cyp2 Gene Expression in Adult Mouse Liver

, 2022
Aram Shin, David J. Waxman
openalex   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Embryo Transfer Experiments and Ovarian Transplantation Identify the Ovary as the Only Site in Which Nuclear Receptor Interacting Protein 1/RIP140 Action Is Crucial for Female Fertility [PDF]

, 2002
Göran Leonardsson
openalex   +1 more source

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

Journal of Clinical Investigation, 1998
J. Lehmann, D. D. Mckee, M. Watson, T. Willson, John T. Moore, S. Kliewer   +5 more
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

EGF receptor–mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling [PDF]

, 2020
Manuel Chiusa, Wen Hu, J Zienkiewicz, Xiwu Chen, Ming‐Zhi Zhang, Raymond C. Harris, Roberto Vanacore, Jennifer A. Bentz, Giuseppe Remuzzi, Ariela Benigni, Agnes B. Fogo, Wentian Luo, Stavroula Mili, Matthew H. Wilson, Roy Zent, Jacek Hawiger, Ambra Pozzi   +16 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development

, 2020
Joan Font-Díaz, Alba Jiménez‐Panizo, Carmé Caelles, María dM Vivanco, Paloma Pérez, Ana Aranda, Eva Estébanez‐Perpiñá, Antonio Castrillo, Mercedes Ricote, Annabel F. Valledor   +9 more
openalex   +2 more sources

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors [PDF]

, 2014
Jeffery S. Tessem, Larry G. Moss, Lily C. Chao, Michelle Arlotto, Danhong Lu, Mette V. Jensen, Samuel B. Stephens, Peter Tontonoz, Hans E. Hohmeier, Christopher B. Newgard   +9 more
openalex   +1 more source