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Ubiquitination of nuclear receptors
Clinical Science, 2017Nuclear receptors (NRs) are cellular proteins, which upon ligand activation, act to exert regulatory control over transcription and subsequent expression. Organized via systemic classification into seven subfamilies, NRs partake in modulating a vast expanse of physiological functions essential for maintenance of life.
Jean Pierre Obeid +3 more
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Nuclear receptors and disease: androgen receptor [PDF]
Essays in Biochemistry, 2004 The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal ligand-binding domain and an Nterminal transcription modulatory domain.
Jianhui Wu +8 more
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Annual Review of Entomology, 2012
The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present) and 3 receptors with the DBD only.
Rodrigo A. Velarde +2 more
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The nuclear receptors (NRs) of metazoans are an ancient family of transcription factors defined by conserved DNA- and ligand-binding domains (DBDs and LBDs, respectively). The Drosophila melanogaster genome project revealed 18 canonical NRs (with DBDs and LBDs both present) and 3 receptors with the DBD only.
Rodrigo A. Velarde +2 more
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Overview of Nomenclature of Nuclear Receptors
Pharmacological Reviews, 2006Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other receptor systems, in the appreciation that ligands may exert very diverse pharmacology, based on their individual chemical structure and the allosteric changes induced in the receptor/accessory protein complex.
Germain, Pierre +4 more
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Nuclear Receptors in Liver Disease Δ
Hepatology, 2011Abstract Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as ...
Wagner +3 more
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Annals of the New York Academy of Sciences, 2007
Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
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Abstract: Nuclear receptors (NRs) represent a class of ligand‐dependent and ‐independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the ...
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Dimerization of Nuclear Receptors
2013Multicellular organisms require specific intercellular communication to properly organize the complex body plan during embryogenesis and maintain its properties and functions during the entire life. While growth factors, neurotransmitters, and peptide hormones bind to membrane receptors, thereby inducing the activity of intracellular kinase cascades or
Pierre Germain, William Bourguet
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Nuclear receptors in disease: the oestrogen receptors
Essays in Biochemistry, 2004For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects.
Jan-Åke Gustafsson +2 more
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The evolution of the nuclear receptor superfamily
Essays in Biochemistry, 2004Nuclear receptors form a superfamily of ligand-activated transcription factors implicated in various physiological functions from development to homoeostasis. Nuclear receptors share a common evolutionary history revealed by their conserved structure and by their high degree of sequence conservation.
Escriva, H., Bertrand, S., Laudet, V.
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Science's STKE, 2005
This Teaching Resource provides lecture notes and slides for a class covering nuclear receptors and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the structure of nuclear hormone receptors and then proceeds to describe mechanisms of transcriptional regulation, modulation of ...
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This Teaching Resource provides lecture notes and slides for a class covering nuclear receptors and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the structure of nuclear hormone receptors and then proceeds to describe mechanisms of transcriptional regulation, modulation of ...
openaire +3 more sources