Results 151 to 160 of about 881,535 (329)

Minireview: Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges [PDF]

, 2013
S. Stoney Simons, Dean P. Edwards, Raj Kumar   +2 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors [PDF]

, 2014
Jeffery S. Tessem, Larry G. Moss, Lily C. Chao, Michelle Arlotto, Danhong Lu, Mette V. Jensen, Samuel B. Stephens, Peter Tontonoz, Hans E. Hohmeier, Christopher B. Newgard   +9 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands [PDF]

, 2002
The ultraspiracle protein (USP) is the insect ortholog of the mammalian retinoid X receptor (RXR). Fundamental questions concern the functional role of USP as the heterodimerization partner of insect nuclear receptors such as the ecdysone receptor.
Billas, Isabelle M.L., Iwema, Thomas, Moras, Dino, Sasorith, Souphatta, Wurtz, Jean-Marie   +4 more
core   +3 more sources

Stimulation of facilitated [3H]uridine transport by thyroid hormone in GH1 cells. Evidence for regulation by the thyroid hormone nuclear receptor.

, 1986
Frederick M. Stanley, Jir S. Tsai, Herbert H. Samuels   +2 more
openalex   +1 more source

MED1 Phosphorylation Promotes Its Association with Mediator: Implications for Nuclear Receptor Signaling [PDF]

, 2008
Madesh Belakavadi, Pradeep K. Pandey, Ravi Vijayvargia, Joseph D. Fondell   +3 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR [PDF]

, 2019
Irene Zwarts, Tim van Zutphen, Janine K. Kruit, Weilin Liu, Maaike H. Oosterveer, Henkjan J. Verkade, N. Henriette Uhlenhaut, Johan W. Jonker   +7 more
openalex   +1 more source