Results 121 to 130 of about 959,641 (315)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Expansion microscopy of neutrophil nuclear structure and extracellular traps. [PDF]

Biophys Rep (N Y), 2023
Holsapple JS, Schnitzler L, Rusch L, Baldeweg TH, Neubert E, Kruss S, Erpenbeck L.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluated nuclear structure data file. a manual for preparation of data sets

, 2001
This manual describes the organization and structure of the Evaluated Nuclear Structure Data File (ENSDF). This computer-based file is maintained by the National Nuclear Data Center (NNDC) at Brookhaven National Laboratory for the international Nuclear ...
Tuli, J K, Tuli, J. K.
core   +1 more source

Symmetry/asymmetry within a cylindrical lattice model of nuclear structure predicts cosmic abundance/scarcity

Journal of Physics Communications
Protons and neutrons are the smallest forms of matter with measurable size, and each nucleon has a mix of three up (+2/3) and down (−1/3) quarks. Quarks are treated as point-like particles within polygon-based geometries in order to model the structures ...
Ray Walsh
doaj   +1 more source

Nuclear envelope mechanobiology: linking the nuclear structure and function. [PDF]

Nucleus, 2021
Goelzer M, Goelzer J, Ferguson ML, Neu CP, Uzer G.   +4 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Sky's the LEMit: New insights into nuclear structure regulation of transcription factor activity. [PDF]

Curr Opin Cell Biol, 2021
Mirza AN, Gonzalez F, Ha SK, Oro AE.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Shell-model study of 58Ni using quantum computing algorithm

New Journal of Physics
This study presents a simulated quantum computing approach for the investigation into the shell-model energy levels of ^58 Ni through the application of the variational quantum eigensolver (VQE) method in combination with a problem-specific ansatz.
Bharti Bhoy, Paul Stevenson
doaj   +1 more source