Results 131 to 140 of about 402,881 (242)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Improving the hole picture: towards a consensus on the mechanism of nuclear transport. [PDF]

Biochem Soc Trans, 2023
Cowburn D, Rout M.
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Evaluating transport conditions of conventional, widely used EDTA blood tubes for gene expression analysis in comparison to expensive, specialized PAXgene tubes in preparedness for radiological and nuclear events

, 2023
Simone Schüle, Patrick Ostheim, Razan Muhtadi, Samantha Stewart, Gwendolyn Kaletka, Cornelius Hermann, Matthias Port, Michael Abend   +7 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The nuclear transport factor CSE1 drives macronuclear volume increase and macronuclear node coalescence in Stentor coeruleus. [PDF]

iScience, 2023
McGillivary RM, Sood P, Hammar K, Marshall WF.   +3 more
europepmc   +1 more source

Fear itself: Assessing the risks of transporting high-level nuclear waste

, 2019
Fred Dilger
openalex   +1 more source

Essential role of active nuclear transport in apoptosis [PDF]

, 1997
Noriko Yasuhara, Yutaka Eguchi, Taro Tachibana, Naoko Imamoto, Yoshihiro Yoneda, Yoshihide Tsujimoto   +5 more
openalex   +1 more source

3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine [PDF]

, 2023
Yan Li, Zhenyu Zhong, Cunjing Xu, Xiaodan Wu, Jiaqi Li, Weiyong Tao, Jianglin Wang, Yingying Du, Shengmin Zhang   +8 more
openalex   +1 more source