Results 141 to 150 of about 420,473 (212)

YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome. [PDF]

PLoS Pathog, 2022
Lee JH, Kwon M, Lim WY, Yoo CR, Yoon Y, Han D, Ahn JH, Yoon K.   +7 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

LAMP5 modulates IRF4 stability and nuclear transport: a critical mechanism in myeloma progression and therapy. [PDF]

Oncogene
Li Z, Liu R, Fang Z, Chen R, Yang D, Li Y, Liu S, Wang C, Liu H.   +8 more
europepmc   +1 more source

Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors. [PDF]

Sci Rep, 2022
Jafarinia H, Van der Giessen E, Onck PR.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1. [PDF]

Virulence
Xue M, Huang C, Jiang X, Zhou S, Yan Y, Dong C, Chen Z, Dai J.   +7 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Protein folding and quality control during nuclear transport. [PDF]

Curr Opin Cell Biol
Mallik S, Poch D, Burick S, Schlieker C.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Cytoplasmic retention of dengue virus capsid protein by metformin impairing nuclear transport. [PDF]

J Gen Virol
Puello-Nakayama IC, Hernandez-Castillo J, Castillo JM, Talamás-Lara D, Palacios-Rápalo SN, Del Ángel RM.   +5 more
europepmc   +1 more source