Results 171 to 180 of about 339,303 (197)
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Journal of Cell Science, 1989
ABSTRACT In this paper, progress towards the goal of understanding communication between the nucleus and cytoplasm using an in vitro system is reviewed. To probe the mechanism of nuclear targeting, we developed an in vitro transport system and have begun to dissect the highly selective process of nuclear transport.
Douglass J. Forbes +4 more
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ABSTRACT In this paper, progress towards the goal of understanding communication between the nucleus and cytoplasm using an in vitro system is reviewed. To probe the mechanism of nuclear targeting, we developed an in vitro transport system and have begun to dissect the highly selective process of nuclear transport.
Douglass J. Forbes +4 more
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Cellular and Molecular Life Sciences, 2001
The term nuclear transport, refers to the movement of a large variety of macromolecules both into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A single type of channel, the nuclear pore complex, mediates all movement across the nuclear envelope.
Anita H. Corbett, B. Booth Quimby
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The term nuclear transport, refers to the movement of a large variety of macromolecules both into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A single type of channel, the nuclear pore complex, mediates all movement across the nuclear envelope.
Anita H. Corbett, B. Booth Quimby
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Inhibitors of nuclear transport
Current Opinion in Cell Biology, 2019Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated by members of the Importin (IMP) superfamily of transporters of α- and β-types. The first inhibitor of nuclear transport, leptomycin B (LMB), was shown to be a specific inhibitor of the IMPβ homologue Exportin 1 (EXP1) almost 20 years ago, but it has only ...
David A. Jans +2 more
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2002
The regulated traffic of cargoes between nucleus and cytoplasm is now thought rather to be the rule than the exception in nuclear transport. The biological importance of regulated nuclear transport is intuitively suggestive. A fast transcriptional response may be produced by rapid nuclear import of a transcription factor.
Helmut Ruis, Christoph Schüller
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The regulated traffic of cargoes between nucleus and cytoplasm is now thought rather to be the rule than the exception in nuclear transport. The biological importance of regulated nuclear transport is intuitively suggestive. A fast transcriptional response may be produced by rapid nuclear import of a transcription factor.
Helmut Ruis, Christoph Schüller
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2002
Publisher Summary This chapter discusses the process of nuclear protein transport. Work on the mechanism of nuclear transport has led to a fairly detailed understanding of how proteins are targeted for import or export. This work has changed the way in which researchers need to think about potential transport mechanisms for their own protein of ...
Anita H. Corbett +2 more
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Publisher Summary This chapter discusses the process of nuclear protein transport. Work on the mechanism of nuclear transport has led to a fairly detailed understanding of how proteins are targeted for import or export. This work has changed the way in which researchers need to think about potential transport mechanisms for their own protein of ...
Anita H. Corbett +2 more
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Nuclear Transport: Target for Therapy
Clinical Pharmacology & Therapeutics, 2007Drugs directed at plasma membrane receptors target environment-cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol-organellar interfaces.
Timothy J. Nelson +3 more
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Nuclear Protein Transport Pathways
Nephron Experimental Nephrology, 1999Nuclear proteins like transcription factors and ribosomal proteins are synthesized in the cytoplasm and have to be transported into the nucleus to fulfill their functions. The transport of proteins >20–60 kD through the nuclear pore complex (NPC) into the nucleus is an active, energy-requiring process.
Enno Hartmann +2 more
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Mechanisms of nuclear transport and interventions
Advanced Drug Delivery Reviews, 2003One of the more overlooked aspects of drug action and delivery is the exploitation of nucleocytoplasmic shuttling. Eukaryotic cells regulate many biological processes by the compartmentation of specific proteins into designated areas. Drugs that have a direct effect on a single protein must be able to localize to the same site as the protein and ...
David A. Dean, Joshua Z. Gasiorowski
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New Perspectives on Nuclear Transport
Annual Review of Genetics, 2001▪ Abstract A central aspect of cellular function is the proper regulation of nucleocytoplasmic transport. In recent years, significant progress has been made in identifying and characterizing the essential components of the transport machinery. Despite these advances, some facets of this process are still unclear.
Arash Komeili, Erin K. O'Shea
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In or out? Regulating nuclear transport
Current Opinion in Cell Biology, 1999The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors.
Jennifer K. Hood, Pamela A. Silver
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