Results 191 to 200 of about 456,044 (305)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The nuclear transport factor IPO5 revealed as a critical mediator of male germline development†. [PDF]

Biol Reprod
Young JC, Whiley PAF, Sutherland JM, Luu M, Garama DJ, Baker MA, Hogarth CA, Richards EA, Jans DA, McLaughlin EA, Loveland KL.   +10 more
europepmc   +1 more source

Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein. [PDF]

Nat Commun, 2023
Liao CC, Wang YS, Pi WC, Wang CH, Wu YM, Chen WY, Hsia KC.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves. [PDF]

Mol Med Rep
Suzuki T, Naito K, Kubota D, Ueno Y, Negishi-Koga T, Yamamoto Y, Kawakita S, Imazu N, Kawamura K, Hattori N, Ishijima M.   +10 more
europepmc   +1 more source

Characterization of cell-to-cell variation in nuclear transport rates and identification of its sources. [PDF]

iScience, 2023
Durrieu L, Bush A, Grande A, Johansson R, Janzén D, Katz A, Cedersund G, Colman-Lerner A.   +7 more
europepmc   +1 more source

Application of the Monte Carlo transport code MORSE to the calculation of pulsed neutron experiments.

, 1978
An accurate calculation tool is essential for the assessment of nuclear data by the pulsed neutron technique. The Monte Carlo transport code MORSE is such a tool and its application to the calculation of pulsed neutron experiments is presented ...
Rainbow, MT
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Breaking barriers: Respiratory viral strategies targeting the host's nuclear pore complex and nuclear transport pathways. [PDF]

Mol Biol Cell
Udi Y, Aitchison JD, Rout MP, Obado S.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source