Results 201 to 210 of about 456,044 (305)

The Biophysical Basis for Karyopherin-Dependent Ebola Virus VP24 Nuclear Transport. [PDF]

Viruses
Zhao J, Zhang B, Vogel O, Walker BW, Ma LW, Wagner ND, Basler CF, Leung DW, Gross ML, Amarasinghe GK.   +9 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Plant-specific BLISTER modulates miRNA biogenesis by regulating MIR transcription, HYL1 phosphorylation, and nuclear transport in Arabidopsis. [PDF]

Nucleic Acids Res
Wang S, Xin X, Zhang J, Li X, Yang W, Zhang S.   +5 more
europepmc   +1 more source

YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome. [PDF]

PLoS Pathog, 2022
Lee JH, Kwon M, Lim WY, Yoo CR, Yoon Y, Han D, Ahn JH, Yoon K.   +7 more
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1. [PDF]

Virulence
Xue M, Huang C, Jiang X, Zhou S, Yan Y, Dong C, Chen Z, Dai J.   +7 more
europepmc   +1 more source

Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors. [PDF]

Sci Rep, 2022
Jafarinia H, Van der Giessen E, Onck PR.
europepmc   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

LAMP5 modulates IRF4 stability and nuclear transport: a critical mechanism in myeloma progression and therapy. [PDF]

Oncogene
Li Z, Liu R, Fang Z, Chen R, Yang D, Li Y, Liu S, Wang C, Liu H.   +8 more
europepmc   +1 more source

Function of the Nuclear Transport Machinery in Maintaining the Distinctive Compositions of the Nucleus and Cytoplasm. [PDF]

Int J Mol Sci, 2022
Stewart M.
europepmc   +1 more source