Results 51 to 60 of about 6,071,343 (411)
DNA Composites and Applications in Bioanalysis
Advanced Sensor Research, 2023 DNA combined with other functional nanomaterials plays crucial roles in biomedical areas, including bio‐detection, bioimaging, as well as disease diagnosis and treatment.
Zheng Fang, Min Li, Xiaolei Zuo
doaj +1 more source
Origin of Information Encoding in Nucleic Acids through a Dissipation-Replication Relation [PDF]
Entropy 2020, 22(9), 940, 2018 Ultraviolet light incident on organic material can initiate its spontaneous dissipative structuring into chromophores which can then catalyze their own replication. This may have been the case for one of the most ancient of all chromophores dissipating the Archean UVC photon flux, the nucleic acids.
arxiv +1 more source
Locked nucleic acid: tighter is different [PDF]
, 2013 This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity ...
Watts, Jonathan
core +1 more source
Absolute quantification of real-time PCR data with stage signal difference analysis [PDF]
arXiv, 2021 Real-time PCR, or Real-time Quantitative PCR (qPCR) is an effective approach to quantify nucleic acid samples. Given the complicated reaction system along with thermal cycles, there has been long-term confusion on accurately calculating the initial nucleic acid amounts from the fluorescence signals.
arxiv
Beilstein Journal of Organic Chemistry, 2014 Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick [1], we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later appeared the first reports on the chemical synthesis of oligonucleotides with a natural 3'-5' phosphodiester linker by Michelsen and ...
openaire +5 more sources
Toxicity Evaluation of Potassium Sorbate In Vivo with Drosophila Melanogaster
InsectsPotassium sorbate (PS) is a preservative widely used in the food, pharmaceutical, and cosmetics industries. Improper and careless use of PS can lead to various health issues and potential environmental problems.
Xubo Zhang +6 more
doaj +1 more source
Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues
Canadian Journal of Infectious Diseases, 1992 7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models.
Donald F Smee +8 more
doaj +1 more source
Conformational switches control early maturation of the eukaryotic small ribosomal subunit
eLife, 2019 Eukaryotic ribosome biogenesis is initiated with the transcription of pre-ribosomal RNA at the 5’ external transcribed spacer, which directs the early association of assembly factors but is absent from the mature ribosome.
Mirjam Hunziker +5 more
doaj +1 more source
Rigid Base Biasing in Molecular Dynamics enables enhanced sampling of DNA conformations [PDF]
arXiv, 2022 All-atom simulations have become increasingly popular to study conformational and dynamical properties of nucleic acids as they are accurate and provide high spatial and time resolutions. This high resolution however comes at a heavy computational cost and within the time scales of simulations nucleic acids weakly fluctuate around their ideal structure
arxiv
Velocity and processivity of helicase unwinding of double-stranded nucleic acids [PDF]
Journal of Physics: Condensed Matter 17 (2005) S3851--S3869, 2005 Helicases are molecular motors which unwind double-stranded nucleic acids (dsNA) in cells. Many helicases move with directional bias on single-stranded (ss) nucleic acids, and couple their directional translocation to strand separation. A model of the coupling between translocation and unwinding uses an interaction potential to represent passive and ...
arxiv +1 more source