Results 71 to 80 of about 788,142 (267)

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Novel Signal-Enhancing Approaches for Optical Detection of Nucleic Acids—Going beyond Target Amplification

Chemosensors, 2015
Detection of low-abundance nucleic acids is a challenging task, which over the last two decades has been solved using enzymatic target amplification.
Laura Miotke, Maria Carla Barducci, Kira Astakhova   +2 more
doaj   +1 more source

pH‐Tunable Material Properties of Glycine‐Rich Condensates from Tick Bioadhesive

Advanced Functional Materials, EarlyView.
This work studies the influence of pH on the phase separation behavior of a disordered glycine‐rich protein found in tick bioadhesive. The results show profound impact on the propensity of coacervation, condensate microstructure and viscosity, amphiphilicity of the peptides, and effective encapsulation of therapeutic molecules.
Manali Nandy, Udit Ghosh, Ketan A. Ganar, Hans Ippel, Ingrid Dijkgraaf, Siddharth Deshpande   +5 more
wiley   +1 more source

Noninvasive molecular imaging using anti-Trop-2 aptamer for targeted therapy of small cell lung cancer

Journal of Nanobiotechnology
Recent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy.
Yamei Chen, Xuwei Liu, Yang Sun, Keying Liu, Ding Ding, Shaoli Song, Weihong Tan   +6 more
doaj   +1 more source

Recent Applications of Albumin as a Green and Versatile Catalyst in Organic Synthesis

Molecules
Today, biocatalytic methodologies are well established as useful tools in green organic synthesis, since biocatalysts are mild, sustainable, and environmentally friendly catalysts which provide selectivity to the reactions they catalyse.
Estefanía L. Borucki, Luis E. Iglesias
doaj   +1 more source

Organic chemical approach to photo-crosslinks of nucleic acids to proteins [PDF]

, 1980
Teruo Matsuura, Isao Saito, Satoru Ito, H. Sugiyama, Tetsuya Shinmura   +4 more
openalex   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Chemoselective Sequential Polymerization: An Approach Toward Mixed Plastic Waste Recycling

Advanced Functional Materials, EarlyView.
Inspired by biological protein metabolism, this study demonstrates the closed‐loop recycling of mixed synthetic polymers via ring‐closing depolymerization followed by a chemoselective sequential polymerizations process. The approach recovers pure polymers from mixed feedstocks, even in multilayer formats, highlighting a promising strategy to overcome a
Gadi Slor, Youwei Ma, Hyunwoo Park, Tae‐Lim Choi, Damien Guironnet, Francesco Stellacci   +5 more
wiley   +1 more source

Gene circuit-based sensors

Fundamental Research
As an important branch of biosensors, gene circuit-based biosensors constructed based on synthetic biology concepts can sense specific substances to be measured and converted into specific signal outputs.
Xinyue Guo, Min Li, Xiaolei Zuo
doaj   +1 more source

Multiplex Nucleic Acid Suspension Bead Arrays for Detection and Subtyping of Filoviruses [PDF]

, 2015
Cecilia Bergqvist, Petra Holmström, Gunnel Lindegren, Nina Lagerqvist, Mikael Leijon, Kerstin I. Falk   +5 more
openalex   +1 more source