Results 71 to 80 of about 781,538 (317)

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins

Pharmaceutics
Background: Cell membrane proteins play crucial roles in signal transduction and nutrient transport. Many membrane proteins are reportedly overexpressed in cancer cells, which is closely related to cancer progression.
Yang Sun, Yichen Huang, Daiquan Chen, Shangjiu Hu, Tao Pan, Yuanding Liu, Ruowen Wang, Weihong Tan   +7 more
doaj   +1 more source

A one-pot CRISPR/Cas13a-based contamination-free biosensor for low-cost and rapid nucleic acid diagnostics

, 2022
Fei Hu, Yan‐Fei Liu, Shuhao Zhao, Zengming Zhang, Xichen Li, Niancai Peng, Zhuangde Jiang   +6 more
openalex   +2 more sources

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

A novel bispecific siRNA concept: Efficient dual knockdown of YAP1 and WWTR1 with a single guide strand

Molecular Therapy: Nucleic Acids
Yes-associated protein (YAP, encoded by YAP1) and transcriptional coactivator with PDZ-binding motif (TAZ, encoded by WWTR1) are master transcriptional regulators in the Hippo pathway. Because of their complementary roles, simultaneously inhibiting these
Kaito Ueda, Yuki Yamada, Hiroyuki Tanaka, Tatsuki Sato, Jumpei Sasaki, Sachiko Sakamoto, Kenjiro Minomi, Hiroshi Yamada, Masayuki Sugimoto   +8 more
doaj   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Evaluation of a high-throughput nucleic acid extraction method for the detection of Mycobacterium avium subsp. paratuberculosis in bovine fecal samples by PCR [PDF]

, 2021
Nagaraja Thirumalapura, Willard Feria, Eric C Hue, Corey Zellers, Deepanker Tewari   +4 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Extraction of Viral Nucleic Acids with Carbon Nanotubes Increases SARS-CoV-2 Quantitative Reverse Transcription Polymerase Chain Reaction Detection Sensitivity

, 2021
Sanghwa Jeong, Eduardo González‐Grandío, Nicole Navarro, Rebecca L. Pinals, Francis Ledesma, Darwin Yang, Markita P. Landry   +6 more
openalex   +2 more sources

Rapid point of care testing for four bacterial sexually transmitted infections using the portable isothermal loop-mediated nucleic acid amplification eazyplex platform [PDF]

, 2023
Ece T. Esitgen Germaner, Lars Wassill, Karl Dichtl, Julia Roider, Ulrich Seybold   +4 more
openalex   +1 more source