Results 121 to 130 of about 194,899 (239)

Mass‐Manufactured Gradient Plasmonic Metasurfaces for Enhanced Mid‐IR Spectrochemical Analysis of Complex Biofluids

Advanced Materials, EarlyView.
This article presents a surface‐enhanced infrared absorption spectroscopy (SEIRAS) platform using mass‐manufactured gradient plasmonic metasurfaces, overcoming limitations in analyzing real‐world biosamples. The technology achieves 20‐fold signal enhancement and demonstrates superior molecular fingerprinting capabilities.
Samir Rosas, Shovasis Kumar Biswas, Wihan Adi, Furkan Kuruoglu, Aidana Beisenova, Manish S. Patankar, Filiz Yesilkoy   +6 more
wiley   +1 more source

The structural basis of differential DNA sequence recognition by restriction–modification controller proteins [PDF]

, 2012
Ball, Neil J., Kneale, Geoff, McGeehan, John, Streeter, Simon, Thresh, Sarah   +4 more
core   +1 more source

Molecular recognition and structural plasticity in amyloid-nucleic acid complexes. [PDF]

J Struct Biol
Kukreja R, Latham MP.
europepmc   +1 more source

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

Size-exclusion chromatography with post-column nucleic acid staining and fluorescence detection for sensitive ribonucleic acid analysis. [PDF]

Anal Bioanal Chem
Hoevelmann Y, Ratter A, Merkel F, Hickert S, Konishcheva E.   +4 more
europepmc   +1 more source

Bringing Attomolar Detection to the Point‐of‐Care with Nanopatterned DNA Origami Nanoantennas

Advanced Materials, EarlyView.
Single DNA molecules are captured within the hotspots of DNA origami NanoAntennas arranged on a chip surface. Fluorescence is amplified, enabling direct detection on a point‐of‐care‐compatible imaging setup (visualized as bright signals against a dark background).
Renukka Yaadav, Kateryna Trofymchuk, Mihir Dass, Vivien Behrendt, Benedikt Hauer, Jan Schütz, Cindy Close, Michael Scheckenbach, Giovanni Ferrari, Leoni Mäurer, Sophia Sebina, Viktorija Glembockyte, Tim Liedl, Philip Tinnefeld   +13 more
wiley   +1 more source

Structural insights into transcriptional regulation by the helicase RECQL5. [PDF]

Nat Struct Mol Biol
Florez Ariza AJ, Lue NZ, Grob P, Kaeser B, Fang J, Kassube SA, Nogales E.   +6 more
europepmc   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Halogenation of nucleic acid structures: from chemical biology to supramolecular chemistry. [PDF]

RSC Chem Biol
Nicolau C, Requena-Ramírez J, González-García J, Bauzá A.   +3 more
europepmc   +1 more source

3D Printing of Conducting Polymer Hydrogels for Electrostimulation‐Assisted Tissue Engineering

Advanced Materials, EarlyView.
This review highlights nanosized inherently conducting polymers (ICPs) as promising ink constituents for 3D printing of conducting hydrogel (CH)‐based electrostimulation (ES) devices. ICP‐based ink formulation, 3D printing, and solidification strategies are discussed, along with the application of 3D‐printed ICP‐based CHs as ES platforms for regulating
Chien Minh Tran, Zhilian Yue, Chunyan Qin, Kusuma B. C. Imani, Mirella Dottori, Robert J. Forster, Gordon G. Wallace   +6 more
wiley   +1 more source