Results 11 to 20 of about 201,489 (346)
Conformational analysis of nucleic acids revisited: Curves+ [PDF]
Nucleic Acids Research, 2009 We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algorithmically simpler and computationally much faster than the earlier Curves approach, although it ...
Richard Lavery +4 more
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Methylation Effects on Nucleic Acid Conformations [PDF]
, 1978 Chemical modification of nucleic acids by alkylating agents continues to be extensively explored from the perspective of chemical mutagenesis and carcinogenesis. Largely through the pioneering in vitro and in vivo studies of Lawley (1961), Lawley and Brookes (1963), Singer (1972), and Reese and coworkers (1965), coupled with theoretical predictions of ...
S. Danyluk +2 more
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Global Studies of Single-Stranded Nucleic Acid Conformation [PDF]
Biophysical Journal, 2013 Unstructured regions of RNA molecules require flexibility to accomplish many biological tasks such as conformational switching and protein recognition. Due to its highly charged backbone, the flexibility of single-stranded RNA is influenced by counterions.
Julie L. Sutton +3 more
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High intrinsic hydrolytic activity of cyanobacterial RNA polymerase compensates for the absence of transcription proofreading factors [PDF]
, 2020 The vast majority of organisms possess transcription elongation factors, the functionally similar bacterial Gre and eukaryotic/archaeal TFIIS/TFS. Their main cellular functions are to proofread errors of transcription and to restart elongation via ...
James, Katherine +2 more
core +2 more sources
Engineering in Life Sciences, 2021 Ferritin is a promising drug delivery platform and has been functionalized through genetic modifications. This work has designed and expressed a dual‐functional engineered human heavy‐chain ferritin (HFn) with the inserted functional peptide PAS and RGDK
Shuang Yin +5 more
doaj +1 more source
Solvent interactions stabilising nucleic acid conformers [PDF]
Nucleic Acids Research, 1989 The transition of oligonucleotides from the B to the A conformation has been studied by the use of simple geometric calculations aimed at finding possible hydration sites which could stabilize these conformations. The method involves the classification of equally spaced grid points, surrounding the oligonucleotide, into groups depending on whether a ...
Robert J. Elliott, Julia M. Goodfellow
openaire +3 more sources
Dependence of interferon induction on nucleic acid conformation. [PDF]
Proceedings of the National Academy of Sciences, 1976 UV and circular dichroism characteristics of duplex analogs belonging to the (A)n-(U)n and (I)n-(C)n series were determined to assign qualitatively the nature of conformational differences caused by 5-pyrimidine and c7 purine substitutions in such duplexes.
Albert M. Bobst +3 more
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Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core +1 more source
Veterinary World, 2013 Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi +5 more
doaj +1 more source
Vitae, 2021 BACKGROUND : Biosensing techniques have been the subject of exponentially increasing interest due to their performance advantages such as high selectivity and sensitivity, easy operation, low cost, short analysis time, simple sample preparation, and real-
Laura Carvajal Barbosa +5 more
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