Results 11 to 20 of about 202,030 (205)

Development of purification process for dual‐function recombinant human heavy‐chain ferritin by the investigation of genetic modification impact on conformation

Engineering in Life Sciences, 2021
Ferritin is a promising drug delivery platform and has been functionalized through genetic modifications. This work has designed and expressed a dual‐functional engineered human heavy‐chain ferritin (HFn) with the inserted functional peptide PAS and RGDK
Shuang Yin, Bingyang Zhang, Jianying Lin, Yongdong Liu, Zhiguo Su, Jingxiu Bi   +5 more
doaj   +1 more source

DNA Renaturation at the Water-Phenol Interface [PDF]

, 2003
We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
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core   +4 more sources

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

Nucleic acid-based biosensors: analytical devices for prevention, diagnosis and treatment of diseases

Vitae, 2021
BACKGROUND : Biosensing techniques have been the subject of exponentially increasing interest due to their performance advantages such as high selectivity and sensitivity, easy operation, low cost, short analysis time, simple sample preparation, and real-
Laura Carvajal Barbosa, Diego Insuasty Cepeda, Andrés Felipe León Torres, Maria Mercedes Arias Cortes, Zuly Jenny Rivera Monroy, Javier Eduardo Garcia Castaneda   +5 more
doaj   +1 more source

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

Spectrophotometric and nucleic acid-binding properties of halloysite clay nanotubes and kaolinite

Heliyon, 2023
Halloysite particles (HNTs) are naturally occurring aluminosilicate nanotubes of low toxicity that have shown great promise for drug and biomolecule delivery into human and animal cells.
Shubha R.L. Malla, Archana Gujjari, Carlos E. Corona, Gary W. Beall, L. Kevin Lewis   +4 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation

CHIMIA, 2013
Recent progress in the synthesis, screening, and self-assembly of nucleic acid–tagged peptidic libraries is reviewed.
Kalyan K. Sadhu, Nicolas Winssinger
doaj   +1 more source

Structural visualization of key steps in human transcription initiation. [PDF]

, 2013
Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie, He, Yuan, NOGALES, Eva, Taatjes, Dylan   +3 more
core   +1 more source

Quantification bias caused by plasmid DNA conformation in quantitative real-time PCR assay. [PDF]

PLoS ONE, 2011
Quantitative real-time PCR (qPCR) is the gold standard for the quantification of specific nucleic acid sequences. However, a serious concern has been revealed in a recent report: supercoiled plasmid standards cause significant over-estimation in qPCR ...
Chih-Hui Lin, Yu-Chieh Chen, Tzu-Ming Pan   +2 more
doaj   +1 more source