Results 11 to 20 of about 451,143 (385)

The electrostatic field of DNA: the role of the nucleic acid conformation

Nucleic Acids Research, 1982
Calculations of the electrostatic field of DNA in two very different double helical conformations, A and Z, are reported and compared with the results previously obtained for B-DNA. Striking contrasts between these fields and the associated electrostatic potentials are brought into evidence.
Lavery, R., Pullman, B.
openaire   +5 more sources

Dependence of interferon induction on nucleic acid conformation.

Proceedings of the National Academy of Sciences of the United States of America, 1976
Albert M. Bobst, Paul F. Torrence, Sofia Kouidou, Bernhard Witkop   +3 more
openalex   +3 more sources

Impact of modified ribose sugars on nucleic acid conformation and function

, 2017
Marina G. Evich, Alexander M. Spring‐Connell, Markus W. Germann   +2 more
openalex   +2 more sources

The Z-nucleic acid sensor ZBP1 in health and disease

Journal of Experimental Medicine, 2023
ZBP1 is an innate immune sensor for double-stranded nucleic acids adopting the Z conformation. Z-RNA/DNA is generated during viral infections and in autoinflammation and cancer.
J. Maelfait, J. Rehwinkel
semanticscholar   +1 more source

Optimizing scoring function of protein-nucleic acid interactions with both affinity and specificity. [PDF]

PLoS ONE, 2013
Protein-nucleic acid (protein-DNA and protein-RNA) recognition is fundamental to the regulation of gene expression. Determination of the structures of the protein-nucleic acid recognition and insight into their interactions at molecular level are vital ...
Zhiqiang Yan, Jin Wang
doaj   +1 more source

A Nonafluoro Nucleoside as a Sensitive ¹⁹F NMR Probe of Nucleic Acid Conformation

Organic Letters, 2008
Nivrutti B. Barhate, Rekha N. Barhate, Pavol Čekan, Gary P. Drobny, Snorri Th. Sigurdsson   +4 more
openalex   +2 more sources

Structural basis of R-loop recognition by the S9.6 monoclonal antibody

Nature Communications, 2022
The S9.6 monoclonal antibody is widely used to map R-loops genome wide. Here, Bou-Nader et al., define the nucleic acid-binding specificity of S9.6 and report its crystal structures free and bound to a hybrid, which reveal the asymmetric recognition of ...
Charles Bou-Nader, Ankur Bothra, David N. Garboczi, Stephen H. Leppla, Jinwei Zhang   +4 more
doaj   +1 more source

Metal-Binding Antimicrobial Peptide SIF4 Kills Escherichia coli by Targeting Cytoplasmic Biomacromolecules without Cytoplasmic Membrane Damage: A Mechanistic Study [PDF]

Shipin Kexue, 2023
To explore how metal-binding antimicrobial peptide SIF4 kills foodborne Escherichia coli by targeting nucleic acid and protein in the cytoplasmic membrane without cytoplasmic membrane damage, the effect of SIF4 on intracellular nucleic acid biosynthesis ...
LI Yuzhen, XIAO Huaiqiu, LIU Miao, WANG Lin, ZENG Mengqi, ZHAO Mouming
doaj   +1 more source

Development of purification process for dual‐function recombinant human heavy‐chain ferritin by the investigation of genetic modification impact on conformation

Engineering in Life Sciences, 2021
Ferritin is a promising drug delivery platform and has been functionalized through genetic modifications. This work has designed and expressed a dual‐functional engineered human heavy‐chain ferritin (HFn) with the inserted functional peptide PAS and RGDK
Shuang Yin, Bingyang Zhang, Jianying Lin, Yongdong Liu, Zhiguo Su, Jingxiu Bi   +5 more
doaj   +1 more source

Structure-based deep learning for binding site detection in nucleic acid macromolecules

NAR Genomics and Bioinformatics, 2021
Structure-based drug design (SBDD) targeting nucleic acid macromolecules, particularly RNA, is a gaining momentum research direction that already resulted in several FDA-approved compounds.
Igor Kozlovskii, Petr Popov
semanticscholar   +1 more source