Results 201 to 210 of about 369,422 (270)

Exploring the conformations of nucleic acids

Journal of Functional Programming, 1995
AbstractThis paper presents an application of functional programming in the field of molecular biology: exploring the conformations of nucleic acids. TheNucleic Acid three-dimensional structure determination problem(NA3D) and a constraint satisfaction algorithm are formally described.
Marcel Turcotte, Guy Lapalme, François Major   +2 more
openaire   +1 more source

Two contiguous conformations in a nucleic acid duplex [PDF]

Nature, 1978
DNA CONFORMATIONS and properties depend on DNA sequence and on environmental conditions1–3. It has been suggested that specific regulatory sites on DNA might have unique secondary conformations2. Conformational transitions, and the propagation of these transitions along a DNA helix, have been proposed as mechanistic steps in RNA transcription4 and DNA ...
David R. Kearns, David R. Kearns, Thomas A. Early, Thomas A. Early, Erik Selsing, Erik Selsing, Robert D. Wells, Robert D. Wells   +7 more
openaire   +2 more sources

Conformations of double-helical nucleic acids

Nature, 1976
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative ...
V. E. Khutorsky, V. I. Poltev
openaire   +3 more sources

Dependence of purine 8C‐H exchange on nucleic acid conformation and base‐pairing geometry: A dynamic probe of DNA and RNA secondary structures

Biopolymers, 1985
Laser Raman spectroscopy is employed as a probe of hydrogen isotope exchange in nucleic acids exhibiting different secondary structures. The rates for deuterium exchange of 8C‐H groups in adenine (A), hypoxanthine (I), and guanine (G) residues of ribo ...
J. Benevides, G. Thomas
semanticscholar   +1 more source

A Framework Nucleic Acid Based Robotic Nanobee for Active Targeting Therapy

Advanced Functional Materials, 2020
DNA nanotechnology has provided new strategies and platforms for cargo delivery. However, DNA‐based nanostructures utilized for cargo delivery have mainly focused on static structures and passive targeting.
Taoran Tian, Dexuan Xiao, Tao Zhang, Yanjing Li, Sirong Shi, Wenyu Zhong, P. Gong, Zhangqian Liu, Qian Li, Yunfeng Lin   +9 more
semanticscholar   +1 more source

Selective Introduction of Nucleic Acids into Metal Organic Framework by Size, Conformation and Stability.

Journal of the American Chemical Society, 2020
We report the use metal organic frameworks for the selective inclusion of nucleic acids with different size, shape and capability of conformational transition.
Shuang Peng, Binglin Bie, Hongnan Jia, Heng Tang, Xiong Zhang, Yuqing Sun, Qi Wei, Fan Wu, Yushu Yuan, Hexiang Deng, Xiang Zhou   +10 more
semanticscholar   +1 more source

Antimicrobials that affect the synthesis and conformation of nucleic acids [PDF]

Revue Scientifique et Technique de l'OIE, 2012
Several antimicrobials act by inhibiting the synthesis of nucleic acids (rifamycins, sulfamides, diaminopyridines), modifying their conformation (quinolones, coumarins) or causing irreversible lesions (nitroimidazoles, nitrofurans). The resistance mechanisms are: a reduction in intracytoplasmic accumulation, modification of the target or the production
T Guillard, E Cambau
openaire   +2 more sources

Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug.

Biochemistry, 1999
BBR3464, a charged trinuclear platinum compound, is the first representative of a new class of anticancer drugs to enter phase I clinical trials. The structure of BBR3464 is characterized by two [trans-PtCl(NH(3))(2)] units linked by a tetraamine [trans ...
M. Kloster, J. Hannis, D. Muddiman, N. Farrell   +3 more
semanticscholar   +1 more source

Nucleic acid conformation diversity: from structure to function and regulation

, 2001
Nucleic acids are the structural supports of genetic material and therefore the key factors in many vital cellular processes. The double-stranded right-handed helix is a regular conformation adopted by both DNA and RNA in cells, but an increasing ...
P. Belmont, J. Constant, M. Demeunynck
semanticscholar   +1 more source

Conformational Flexibility of Nucleic Acids

1983
In consideration of the importance of conformational flexibility to the functioning of nucleic acids, NMR studies have been carried out to elucidate aspects of dynamics with molecular Mechanics calculations providing supplementary insight. Analysis of 31P and 13C NMR relaxation data in terms of plausible motions in a DNA helix indicate that winding and
Peter Bendel, Joe W. Keepers, Joseph Murphy-Boesch, Peter A. Kollman, Jacqueline L. James, John Taylor, Aviva Lapidot, Thomas L. James   +7 more
openaire   +2 more sources