Results 201 to 210 of about 194,899 (239)

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

The mechanism of lineage-specific tRNA recognition by bacterial tryptophanyl-tRNA synthetase and its implications for inhibitor discovery. [PDF]

Nucleic Acids Res
Peng X, Xia K, Xiao L, Qi H, Huang Q, Xiang M, Han L, Qiu H, Gu Q, Chen B, Zhou H.   +10 more
europepmc   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

ATPase-dependent duplex nucleic acid unwinding by SARS-CoV-2 nsP13 relies on facile binding and translocation along single-stranded nucleic acid. [PDF]

J Biol Chem
Park J, Jeong YJ, Chauhan K, Koh HR, Kim DE.   +4 more
europepmc   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Supramolecular Recognition of a DNA Four-Way Junction by an M₂L₄ Metallo-Cage, Inspired by a Simulation-Guided Design Approach. [PDF]

Angew Chem Int Ed Engl
Dettmer SJ, Williams HD, Williams HD, Napier R, Beames JM, Walker-Griffiths S, Craggs TD, Hannon MJ.   +7 more
europepmc   +1 more source

Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology. [PDF]

Int J Mol Sci
Wang L, Liu Y, Xian X, Zhang H.
europepmc   +1 more source

3D structure and stability prediction of DNA with multi-way junctions in ionic solutions. [PDF]

PLoS Comput Biol
Wang X, Shi YZ.
europepmc   +1 more source

Methylation of Cytidine 1407 Increases the Lifetimes of the A-Site Ground and Excited States of <i>E. coli</i> 16S Ribosomal RNA. [PDF]

J Am Chem Soc
Hilber S, Marotto A, Mitteregger C, Tollinger M, Kreutz C.   +4 more
europepmc   +1 more source

The Progress and Evolving Trends in Nucleic-Acid-Based Therapies. [PDF]

Biomolecules
Liu Y, Wang C, Fu X, Ren M.
europepmc   +1 more source