Results 221 to 230 of about 438,619 (385)

Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain. [PDF]

Angew Chem Int Ed Engl
Weil-Ktorza O, Naveh-Tassa S, Fridmann-Sirkis Y, Despotović D, Cherukuri KP, Corlett T, Levy Y, Metanis N, Longo LM.   +8 more
europepmc   +1 more source

The conformation of single‐stranded nucleic acids [PDF]

, 1990
Jean Paquette, K. Nicoghosian, Guo‐rong QI, Nicole Beauchemin, Robert Cedergren   +4 more
openalex   +1 more source

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei, Qin Wu, Weihong Tan   +13 more
wiley   +1 more source

Lock and key: locked G quadruplexes could be the key to new modalities in nucleic acid therapeutics. [PDF]

RSC Med Chem
Kulshreshtha NN, Barthélémy P.
europepmc   +1 more source

Design, synthesis, and analysis of conformationally constrained nucleic acids [PDF]

, 1998
Gary D. Glick
openalex   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Precise detection of G-quadruplexs in living systems: principles, applications, and perspectives. [PDF]

Chem Sci
Li H, Jin Z, Gao S, Kuang S, Lei C, Nie Z.   +5 more
europepmc   +1 more source

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery

Advanced Science, EarlyView.
A high‐strength pH‐responsive hydrogel‐forming microneedle integrates gradient solvent replacement to enhance the mechanical properties of the acrylonitrile‐acrylic acid copolymer network, ensuring robust transdermal penetration and long‐term drug release.
Hui Li, Fengzhen Meng, Chengwei Hu, Zhiyun Wu, Liuzhi Hao, Caijun Sun, Lijing Fang, Fan Pan, Shaoquan Bian, Huipeng Li, Mingjun Li, Bo Liu, Xiaoli Zhao   +12 more
wiley   +1 more source

Synthetic CRISPR Networks Driven by Transcription Factors via Structure-Switching DNA Translators. [PDF]

J Am Chem Soc
Capelli L, Marzari S, Spezzani E, Bertucci A.   +3 more
europepmc   +1 more source

Interaction of p55 Reverse Transcriptase from theSaccharomyces cerevisiae Retrotransposon Ty3 with Conformationally Distinct Nucleic Acid Duplexes [PDF]

, 2000
Jason W. Rausch, Marion K.Bona-Le Grice, M. Henrietta, McMahon Nymark, Jennifer T. Miller, Stuart F.J. Le Grice   +5 more
openalex   +1 more source