Results 251 to 260 of about 438,619 (385)

Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology. [PDF]

Int J Mol Sci
Wang L, Liu Y, Xian X, Zhang H.
europepmc   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

The mechanism of lineage-specific tRNA recognition by bacterial tryptophanyl-tRNA synthetase and its implications for inhibitor discovery. [PDF]

Nucleic Acids Res
Peng X, Xia K, Xiao L, Qi H, Huang Q, Xiang M, Han L, Qiu H, Gu Q, Chen B, Zhou H.   +10 more
europepmc   +1 more source

A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
The ssLAMP method amplifies the nucleic acid of pathogen and identifies SNP mutations. By combining the portable detection device with smartphone‐based analysis software, enables rapid, on‐site SNP detection and genotyping of SARS‐Cov‐2 Omicron variants, providing a cost‐effective and field‐deployable solution for precise pathogen identification in ...
Qijie Lin, Hongchao Gou, Xiaoyun Qu, Kaiyuan Jia, Yuhui Deng, Dan Li, Qianyi Cai, Yucen Liang, Xiaozhen Xu, Yanbin Li, Jianhan Lin, Letian Li, Yuhang Jiang, Shouwen Du, Lingcong Deng, Bailing Yan, Ruidong Liu, Chang Li, Jianmin Zhang, Ming Liao   +19 more
wiley   +1 more source

NAIRDB: a database of Fourier transform infrared (FTIR) data for nucleic acids. [PDF]

Nucleic Acids Res
Balduzzi E, Geinguenaud F, Sordyl D, Maiti S, Farsani MA, Nikolaev G, Arluison V, Bujnicki JM.   +7 more
europepmc   +1 more source

tRF‐5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Acute respiratory distress syndrome (ARDS) is a severe lung condition with limited treatments, often triggered by overactive endothelial cells (ECs). It is identified that macrophage‐derived secretory autophagosomes (MSAPs) exacerbate lung damage by activating EC function.
Xing‐xing Zhu, Han Li, Shuang‐feng Zi, Ying Tang, Na Liu, Ke‐xin Li, Shi‐ke Geng, Hui‐qing Lu, Zhi‐kang Xie, Xin‐yi Xu, Yi‐ting Wei, Li‐xin Wang, Tao Liu, Jie Chao, Yi Yang, Hai‐bo Qiu, Wei Huang, Ling Liu   +17 more
wiley   +1 more source

The Progress and Evolving Trends in Nucleic-Acid-Based Therapies. [PDF]

Biomolecules
Liu Y, Wang C, Fu X, Ren M.
europepmc   +1 more source

Carbon-13 NMR in conformational analysis of nucleic acid fragments 3. The magnitude of torsional angle in d(TpA) from CCOP and HCOP NMR coupling constants

, 1984
Peter P. Lankhorst, C. A. G. Haasnoot, Cornelis Erkelens, C. Altona   +3 more
openalex   +2 more sources

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Advanced Science, EarlyView.
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim, Gyeongseok Yang, Chaelyeong Lim, Gaeun Park, Jaemo Lee, Youjung Sim, Ja‐Hyoung Ryu   +6 more
wiley   +1 more source

Supramolecular Recognition of a DNA Four-Way Junction by an M₂L₄ Metallo-Cage, Inspired by a Simulation-Guided Design Approach. [PDF]

Angew Chem Int Ed Engl
Dettmer SJ, Williams HD, Napier R, Beames JM, Walker-Griffiths S, Craggs TD, Hannon MJ.   +6 more
europepmc   +1 more source