Results 251 to 260 of about 205,585 (348)

Factors Determining Conformation of Nucleic Acids : With Special Reference to Effects of Glycosidic Conformation on Handedness of the Helix

, 1983
Seiichi Uesugi
openalex   +2 more sources

Unique Aerofoil‐Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale‐up

Advanced Science, EarlyView.
This study presents aerofoiled microfluidic structures optimized for efficient mixing and lipid nanoparticle (LNP) formation across broad flow rates. Based on this design, two dedicated systems are introduced: MiNANO‐form for high‐throughput formulation screening and MiNANO‐scale for continuous large‐scale production, enabling reproducible, high ...
Dongsheng Liu, Mingzhi Yu, Yuguo Zhang, Allen Mathew, Tianyu Guan, Liang Yao, Xianqing Wang, Wenxin Wang, Nan Zhang   +8 more
wiley   +1 more source

Force fields matter in DNA pol $$ \eta $$ mechanistic analysis. [PDF]

Protein Sci
Osadchey R, Cui Q.
europepmc   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Marginal Stability of the YB1 Cold-Shock Domain in Cells Enables Binding of Multiple Nucleic Acids. [PDF]

Adv Sci (Weinh)
Shrestha P, Ribeiro SS, Aurich J, Herrmann C, Ebbinghaus S.   +4 more
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Filament assembly induced by the recognition of target DNA activates the prokaryotic Argonaute SPARDA system. [PDF]

Nat Commun
Zhang W, Jiang Y, Li Y, Zhen X, Xu S, Xia NS, Li S, Wang X, Zheng Q, Ouyang S.   +9 more
europepmc   +1 more source

Local Nucleic Acid Base Conformation Study by Guanine Fluorescent Analogue 6- Methyl Isoxanthopterin (6-MI) Labeled DNA

, 2019
Huiying Ji
openalex   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

A minimal RNA-cleaving DNAzyme and its catalytic mechanism. [PDF]

Nucleic Acids Res
Yamasaki K, Inomata R, Yamasaki T, Kubota T, Miyashita N, Takeuchi K, Miyagishi M.   +6 more
europepmc   +1 more source