Results 21 to 30 of about 194,899 (239)

Methylation Effects on Nucleic Acid Conformations [PDF]

, 1978
Chemical modification of nucleic acids by alkylating agents continues to be extensively explored from the perspective of chemical mutagenesis and carcinogenesis. Largely through the pioneering in vitro and in vivo studies of Lawley (1961), Lawley and Brookes (1963), Singer (1972), and Reese and coworkers (1965), coupled with theoretical predictions of ...
Danyluk, S.S., Ainsworth, C.F., MacCoss, M.   +2 more
openaire   +2 more sources

Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules [PDF]

, 2017
G-quadruplexes are nucleic acids structures stabilized by physiological concentration of potassium ions. Because low stability G-quadruplexes are hardly detectable by mass spectrometry, we optimized solvent conditions: isopropanol in a triethylamine ...
Scalabrin, Matteo, Palumbo, Manlio, Richter, Sara N.   +2 more
core   +1 more source

RosettaBackrub--a web server for flexible backbone protein structure modeling and design. [PDF]

, 2010
The RosettaBackrub server (http://kortemmelab.ucsf.edu/backrub) implements the Backrub method, derived from observations of alternative conformations in high-resolution protein crystal structures, for flexible backbone protein modeling.
Friedland, Gregory F, Humphris, Elisabeth L, Kortemme, Tanja, Lauck, Florian, Smith, Colin A   +4 more
core   +2 more sources

Conformational classification of functional nucleic acids [PDF]

Nucleic Acids Symposium Series, 1999
The kink parameters would provide the tolerant aspect for irregular helical structure of nucleic acid. Using these kink parameters, the classification of conformation space was carried for the functional nucleic acid molecules. The kink parameters could afford us the simple structural aspects about the constructive parts of functional molecules.
openaire   +3 more sources

Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. [PDF]

, 2016
RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.
Chong, Jenny, Huang, Xuhui, Hwang, Candy S, Kool, Eric T, McKenna, Charles E, Shin, Ji Hyun, Ulrich, Sébastien, Wang, Dong, Wang, Wei, Xu, Liang, Zhang, Lu   +10 more
core   +2 more sources

Dependence of interferon induction on nucleic acid conformation. [PDF]

Proceedings of the National Academy of Sciences, 1976
UV and circular dichroism characteristics of duplex analogs belonging to the (A)n-(U)n and (I)n-(C)n series were determined to assign qualitatively the nature of conformational differences caused by 5-pyrimidine and c7 purine substitutions in such duplexes.
Bernhard Witkop, Sofia Kouidou, Albert M. Bobst, Paul F. Torrence   +3 more
openaire   +3 more sources

Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. [PDF]

, 2006
The archaeal/eukaryotic proliferating cell nuclear antigen (PCNA) toroidal clamp interacts with a host of DNA modifying enzymes, providing a stable anchorage and enhancing their respective processivities.
Andrew S. Doré, Antony W. Oliver, Brunger, Bunting, CCP4, Chang, Chapados, Dalrymple, DeLano, Dianova, Dionne, Dionne, Emsley, Friedrich-Heineken, Gulbis, Helt, Hingorani, Hosfield, Kelman, Kong, Kontopidis, Krishna, Krokan, Laurence H. Pearl, Leslie, Mairi L. Kilkenny, Matsumiya, Matsumoto, Murante, Murshudov, Oyama, Parker, Parrilla-Castellar, Pearl, Roberts, S. Mark Roe, Sakurai, Sarah A. Jones, Shamoo, Shen, Smirnova, Stephen D. Bell, Storoni, Tom, Toueille, Tsuchimoto, Venclovas, Volkmer, Wang   +48 more
core   +4 more sources

Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4 [PDF]

, 2006
The genome of bacteriophage T4 encodes three polynucleotide ligases, which seal the backbone of nucleic acids during infection of host bacteria. The T4Dnl (T4 DNA ligase) and two RNA ligases [T4Rnl1 (T4 RNA ligase 1) and T4Rnl2] join a diverse array of ...
Amitsur, Arabshahi, Bebenek, Begley, Bellacosa, Blondal, Blondal, Cherepanov, Cherepanov, Clepet, Della, Desmond R. Bullard, Doherty, Engler, Fareed, Higgins, Ho, Ho, Kaufmann, Keppetipola, Kornberg, Kuhn, Lavesa-Curto, Lehman, Markham, Martins, Martins, Miller, Moore, Nandakumar, Nandakumar, Nandakumar, Nick McElhinny, Omari, Pascal, Pitcher, Pitcher, Richard P. Bowater, Rossi, Ruiz, Runnels, Rydberg, Sambrook, Sekiguchi, Shuman, Shuman, Snopek, Sriskanda, Stuart, Timson, Tomkinson, Wang, Wang, Weiss, Wilkinson, Wilkinson, Wilkinson, Wood, Wood, Worthey, Yin, Yin   +61 more
core   +4 more sources

Introduction to protein folding for physicists [PDF]

, 2007
The prediction of the three-dimensional native structure of proteins from the knowledge of their amino acid sequence, known as the protein folding problem, is one of the most important yet unsolved issues of modern science.
Abagyan R. A., Arnold V. I., Calera C. Gómez-Moreno, Chothia C., Creighton T. E., Dawkins R., Dawkins R., Drenth J., Dubrovin B. A., Fersht A., Gibson G., Goldstein H., Greiner W., Halgren T. A., Haltia T., Head-Gordon T., Lesk A. M., Levinthal C., Pablo Echenique, Plotkin S. S., Smith C., van Kampen N. G.   +21 more
core   +3 more sources

Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates [PDF]

, 2006
Hairpin polyamide–chlorambucil conjugates containing an {alpha}-diaminobutyric acid ({alpha}-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized {gamma}-DABA turn.
Chou, C. James, Dervan, Peter B., Farkas, Michelle E., Gottesfeld, Joel M., Tsai, Sherry M.   +4 more
core   +4 more sources