Results 21 to 30 of about 451,143 (385)

DNA Renaturation at the Water-Phenol Interface [PDF]

open access: yes, 2003
We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
121   +161 more
core   +3 more sources

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

open access: yesVeterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi   +5 more
doaj   +1 more source

Nucleic acid-based biosensors: analytical devices for prevention, diagnosis and treatment of diseases

open access: yesVitae, 2021
BACKGROUND : Biosensing techniques have been the subject of exponentially increasing interest due to their performance advantages such as high selectivity and sensitivity, easy operation, low cost, short analysis time, simple sample preparation, and real-
Laura Carvajal Barbosa   +5 more
doaj   +1 more source

Structural visualization of key steps in human transcription initiation. [PDF]

open access: yes, 2013
Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie   +3 more
core   +1 more source

Spectrophotometric and nucleic acid-binding properties of halloysite clay nanotubes and kaolinite

open access: yesHeliyon, 2023
Halloysite particles (HNTs) are naturally occurring aluminosilicate nanotubes of low toxicity that have shown great promise for drug and biomolecule delivery into human and animal cells.
Shubha R.L. Malla   +4 more
doaj   +1 more source

Nucleotides: Structure and Properties [PDF]

open access: yes, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

Solvent interactions stabilising nucleic acid conformers [PDF]

open access: yesNucleic Acids Research, 1989
The transition of oligonucleotides from the B to the A conformation has been studied by the use of simple geometric calculations aimed at finding possible hydration sites which could stabilize these conformations. The method involves the classification of equally spaced grid points, surrounding the oligonucleotide, into groups depending on whether a ...
R J, Elliott, J M, Goodfellow
openaire   +2 more sources

Introduction to protein folding for physicists [PDF]

open access: yes, 2007
The prediction of the three-dimensional native structure of proteins from the knowledge of their amino acid sequence, known as the protein folding problem, is one of the most important yet unsolved issues of modern science.
Abagyan R. A.   +21 more
core   +3 more sources

Advances in the Determination of Nucleic Acid Conformational Ensembles [PDF]

open access: yesAnnual Review of Physical Chemistry, 2014
Conformational changes in nucleic acids play a key role in the way genetic information is stored, transferred, and processed in living cells. Here, we describe new approaches that employ a broad range of experimental data, including NMR-derived chemical shifts and residual dipolar couplings, small-angle X-ray scattering, and computational approaches ...
Loïc, Salmon   +2 more
openaire   +2 more sources

Quantification bias caused by plasmid DNA conformation in quantitative real-time PCR assay. [PDF]

open access: yesPLoS ONE, 2011
Quantitative real-time PCR (qPCR) is the gold standard for the quantification of specific nucleic acid sequences. However, a serious concern has been revealed in a recent report: supercoiled plasmid standards cause significant over-estimation in qPCR ...
Chih-Hui Lin   +2 more
doaj   +1 more source

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