Results 61 to 70 of about 202,030 (205)

Conformational transitions in human translin enable nucleic acid binding [PDF]

Nucleic Acids Research, 2013
Translin is a highly conserved RNA- and DNA-binding protein that plays essential roles in eukaryotic cells. Human translin functions as an octamer, but in the octameric crystallographic structure, the residues responsible for nucleic acid binding are not accessible.
Pérez-Cano, Laura, Eliahoo, Elad, Lasker, Keren, Wolfson, Haim J., Glaser, Fabian, Manor, Haim, Bernadó, Pau, Fernández-Recio, Juan   +7 more
openaire   +2 more sources

Pyrrolidine nucleotide analogs with a tunable conformation

Beilstein Journal of Organic Chemistry, 2014
Conformational preferences of the pyrrolidine ring in nucleotide analogs 7–14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the ...
Lenka Poštová Slavětínská, Dominik Rejman, Radek Pohl   +2 more
doaj   +1 more source

The biofilm matrix scaffold of Ps eudomonas aeruginosa contains G-quadruplex extracellular DNA structures

npj Biofilms and Microbiomes, 2021
Extracellular DNA, or eDNA, is recognised as a critical biofilm component; however, it is not understood how it forms networked matrix structures. Here, we isolate eDNA from static-culture Pseudomonas aeruginosa biofilms using ionic liquids to preserve ...
Thomas Seviour, Fernaldo Richtia Winnerdy, Lan Li Wong, Xiangyan Shi, Sudarsan Mugunthan, Yong Hwee Foo, Remi Castaing, Sunil S. Adav, Sujatha Subramoni, Gurjeet Singh Kohli, Heather M. Shewan, Jason R. Stokes, Scott A. Rice, Anh Tuân Phan, Staffan Kjelleberg   +14 more
doaj   +1 more source

Evolutionary Covariant Positions within Calmodulin EF-hand Sequences Promote Ligand Binding [PDF]

, 2018
Intracellular calcium signaling is an essential regulatory mechanism through calcium-mediated signal transduction pathways involved in many cell processes, such as exocytosis, motility, apoptosis, excitability, transcription, and muscle contraction.
Vaidyanathan, Uma
core   +1 more source

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

mSphere, 2016
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR.
Matthew D. Moore, Benjamin G. Bobay, Brittany Mertens, Lee-Ann Jaykus   +3 more
doaj   +1 more source

Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin

Frontiers in Cell and Developmental Biology, 2021
Herein we report that the 18-base telomeric oligodeoxynucleotides (ODNs) designed from the Lactobacillus rhamnosus GG genome promote differentiation of skeletal muscle myoblasts which are myogenic precursor cells. We termed these myogenetic ODNs (myoDNs).
Sayaka Shinji, Koji Umezawa, Koji Umezawa, Yuma Nihashi, Shunichi Nakamura, Takeshi Shimosato, Takeshi Shimosato, Takeshi Shimosato, Takeshi Shimosato, Tomohide Takaya, Tomohide Takaya, Tomohide Takaya, Tomohide Takaya   +12 more
doaj   +1 more source

High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]

, 2017
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S., Kerkour, A., Marquevielle, J., Mergny, J.-L., Salgado, G. F., Yatsunyk, Liliya A.   +5 more
core   +2 more sources

Coarse Graining RNA Nanostructures for Molecular Dynamics Simulations [PDF]

, 2010
A series of coarse-grained models have been developed for the study of the molecular dynamics of RNA nanostructures. The models in the series have one to three beads per nucleotide and include different amounts of detailed structural information.
Bruce A Shapiro, Ercolessi F, Gopal S M, Maxim Paliy, Nielsen S O, Paliy M, Roderick Melnik   +6 more
core   +3 more sources

Computational investigation of locked nucleic acid (LNA) nucleotides in the active sites of DNA polymerases by molecular docking simulations. [PDF]

PLoS ONE, 2014
Aptamers constitute a potential class of therapeutic molecules typically selected from a large pool of oligonucleotides against a specific target. With a scope of developing unique shorter aptamers with very high biostability and affinity, locked nucleic
Vasanthanathan Poongavanam, Praveen K Madala, Torben Højland, Rakesh N Veedu   +3 more
doaj   +1 more source

Nucleic acid-induced NADase activation of a short Sir2-associated prokaryotic Argonaute system

Cell Reports
Summary: Inhibition of nucleic acid targets is mediated by Argonaute (Ago) proteins guided by RNA or DNA. Although the mechanisms underpinning the functions of eukaryotic and “long” prokaryotic Ago proteins (pAgos) are well understood, those for short ...
Dapeng Sun, Kaixiang Zhu, Linyue Wang, Zhixia Mu, Kang Wu, Lei Hua, Bo Qin, Xiaopan Gao, Yumei Wang, Sheng Cui   +9 more
doaj   +1 more source