Results 61 to 70 of about 438,619 (385)

Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein

Molecules, 2021
Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic, Giulia Olivato, Caterina Carraro, Richard Göttlich, Dan Fabris, Barbara Gatto   +5 more
doaj   +1 more source

Reversible DNA i-motif to hairpin switching induced by copper(II) cations [PDF]

, 2015
i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA.
Alberti, Andrew James Gates, Bugaut, Chen, Choi, Choi, Colin John MacDonald, Courtney, Day, Elisé Patricia Wright, Gehring, Han, Henry Albert Day, Howell, Jolad, Kendrick, Kypr, Leroy, Liedl, Liu, Malliavin, Mergny, Mergny, Modi, Ono, Rodriguez, Shi, Smiatek, Smiatek, Wang, Zoë Ann Ella Waller   +30 more
core   +1 more source

The Many (Inter)faces of Anti-CRISPRs: Modulation of CRISPR-Cas Structure and Dynamics by Mechanistically Diverse Inhibitors

Biomolecules, 2023
The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPRs (Acrs), has enabled the development of highly controllable and precise CRISPR-Cas tools.
Helen B. Belato, George P. Lisi
doaj   +1 more source

Revisiting the anomalous bending elasticity of sharply bent DNA [PDF]

, 2015
Several recent experiments suggest that sharply bent DNA has a surprisingly high bending flexibility, but the cause of this flexibility is poorly understood.
Chen, Hu, Cong, Peiwen, Dai, Liang, Doyle, Patrick S., Doyle, Patrick S., van der Maarel, Johan R.C., Yan, Jie   +6 more
core   +2 more sources

Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules [PDF]

, 2017
G-quadruplexes are nucleic acids structures stabilized by physiological concentration of potassium ions. Because low stability G-quadruplexes are hardly detectable by mass spectrometry, we optimized solvent conditions: isopropanol in a triethylamine ...
Scalabrin, Matteo, Palumbo, Manlio, Richter, Sara N.   +2 more
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry

Journal of Nucleic Acids, 2012
“Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability.
Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste   +6 more
doaj   +1 more source

Catalytic mechanism of alpha-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling. [PDF]

, 2013
Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism.
Aherne, Ali, Amyes, Andrea Bodor, András Perczel, Barabas, Barabas, Barabas, Batra, Baxter, Becke, Beáta G. Vértessy, Brunger, Castillo-Acosta, CCP4, Cedergren-Zeppezauer, Chan, Cherepanov, Dauter, DeLano, Dubrovay, Edina Rosta, Emsley, Fiser, Florian, Freeman, Friesner, Galperin, Garcia-Nafria, Garcia-Nafria, García-Nafría, Gerlt, Glowacki, Gonen, Hampton, Horvati, Imre Zagyva, Ivanov, Jiang, Jones, Kabsch, Kamerlin, Kamerlin, Klahn, Kovari, Lahiri, Lamzin, Lari, Larsson, Larsson, Leiros, Leslie, Matthias Wilmanns, Merenyi, Mildvan, Miyahara, Miyahara, Moffat, Mol, Muha, Nagel, Nakamura, Nemeth-Pongracz, Nicholas, Nord, Nord, Nord, Nowotny, Orsolya Barabás, Pauling, Pecsi, Pecsi, Pecsi, Persson, Persson, Prasad, Prasad, Quesada-Soriano, Ramon-Maiques, Rosta, Rosta, Terwilliger, Toth, Van Calenbergh, Varga, Varga, Veronika Németh, Vertessy, Vertessy, Vertessy, Vertessy, Vertessy, Vince I. Grolmusz, Whittingham, Wilson, Wilson, Winn, Wolfenden, Woodcock, Xu, Zoltán Kele, Zoltán Szabadka   +101 more
core   +2 more sources

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source